UniProt Accession

 ANM7_HUMAN; Q9NVM4; B3KPR0; B3KUG9; B4E379; Q96PV5; Q9H9L0 

Genbank Protein ID

 AK001502; AK022739; AK056647; AK097175; AK304605; BC000146; AB067520 

Genbank Nucleotide ID

 BAA91726.1; BAB14215.1; BAG51772.1; BAG53431.1; BAG65391.1; AAH00146.1; BAB67826.1 

Protein Name

 Protein arginine N-methyltransferase 7 

Protein Synonyms/Alias

 Histone-arginine N-methyltransferase PRMT7; [Myelin basic protein]-arginine N-methyltransferase PRMT7 

Gene Name

 PRMT7 

Gene Synonyms/Alias

 KIAA1933 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
2	******MKIFCSRAN	ubiquitination	[1]
42	YADMLHDKDRNVKYY	ubiquitination	[1]
47	HDKDRNVKYYQGIRA	ubiquitination	[1]
109	AAVKIVEKNGFSDKI	ubiquitination	[1]
115	EKNGFSDKIKVINKH	ubiquitination	[1]
121	DKIKVINKHSTEVTV	ubiquitination	[1]
457	DKINIIEKRPELLTN	ubiquitination	[2]
550	HIMDDMIKRALDFRE	ubiquitination	[1, 3]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 

Functional Description

 Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo. 

Sequence Annotation

 ACT_SITE 144 144 By similarity.
 ACT_SITE 153 153 By similarity.  

Keyword

 Alternative splicing; Chromatin regulator; Complete proteome; Cytoplasm; Differentiation; Methyltransferase; Nucleus; Reference proteome; S-adenosyl-L-methionine; Transcription; Transcription regulation; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 692 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0016277; F:[myelin basic protein]-arginine N-methyltransferase activity; IDA:HGNC.
 GO:0042393; F:histone binding; IC:HGNC.
 GO:0044020; F:histone methyltransferase activity (H4-R3 specific); ISS:UniProtKB.
 GO:0035241; F:protein-arginine omega-N monomethyltransferase activity; IDA:UniProtKB.
 GO:0035243; F:protein-arginine omega-N symmetric methyltransferase activity; IDA:UniProtKB.
 GO:0043021; F:ribonucleoprotein complex binding; IPI:UniProtKB.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0043046; P:DNA methylation involved in gamete generation; ISS:UniProtKB.
 GO:0006349; P:regulation of gene expression by genetic imprinting; ISS:UniProtKB.
 GO:0043393; P:regulation of protein binding; IC:HGNC.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0000387; P:spliceosomal snRNP assembly; IMP:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR025799; Arg_MeTrfase.
 IPR025801; Arg_MeTrfase_PMTR7_chr.
 IPR014644; Arg_MeTrfase_PRMT7.
 IPR010456; Ribosomal-L11_MeTrfase_PrmA. 

Pfam

 PF06325; PrmA 

SMART

  

PROSITE

  

PRINTS