CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014327
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Catenin alpha-2 
Protein Synonyms/Alias
 Alpha N-catenin 
Gene Name
 Ctnna2 
Gene Synonyms/Alias
 Catna2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
796LNICSKVKAEVQNLGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation. 
Sequence Annotation
 MOD_RES 2 2 N-acetylthreonine.
 MOD_RES 5 5 Phosphothreonine.
 MOD_RES 6 6 Phosphoserine.
 MOD_RES 261 261 Phosphothreonine.
 MOD_RES 262 262 Phosphoserine.
 MOD_RES 640 640 Phosphoserine.
 MOD_RES 653 653 Phosphothreonine.
 MOD_RES 654 654 Phosphoserine.
 MOD_RES 657 657 Phosphothreonine.
 MOD_RES 901 901 Phosphoserine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Cell adhesion; Cell junction; Cell membrane; Cell projection; Complete proteome; Cytoplasm; Cytoskeleton; Developmental protein; Differentiation; Membrane; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 953 AA 
Protein Sequence
MTSATSPIIL KWDPKSLEIR TLTVERLLEP LVTQVTTLVN TSNKGPSGKK KGRSKKAHVL 60
AASVEQATQN FLEKGEQIAK ESQDLKEELV AAVEDVRKQG ETMRIASSEF ADDPCSSVKR 120
GTMVRAARAL LSAVTRLLIL ADMADVMRLL SHLKIVEEAL EAVKNATNEQ DLANRFKEFG 180
KEMVKLNYVA ARRQQELKDP HCRDEMAAAR GALKKNATML YTASQAFLRH PDVAATRANR 240
DYVFKQVQEA IAGISSAAQA TSPTDEAKGH TGIGELAAAL NEFDNKIILD PMTFSEARFR 300
PSLEERLESI ISGAALMADS SCTRDDRRER IVAECNAVRQ ALQDLLSEYM NNTGRKEKGD 360
PLNIAIDKMT KKTRDLRRQL RKAVMDHISD SFLETNVPLL VLIEAAKSGN EKEVKEYAQV 420
FREHANKLVE VANLACSISN NEEGVKLVRM AATQIDSLCP QVINAALTLA ARPQSKVAQD 480
NMDVFKDQWE KQVRVLTEAV DDITSVDDFL SVSENHILED VNKCVIALQE GDVDTLDRTA 540
GAIRGRAARV IHIINAEMEN YEAGVYTEKV LEATKLLSET VMPRFAEQVE VAIEALSANV 600
PQPFEENEFI DASRLVYDGV RDIRKAVLMI RTPEELEDDS DFEQEDYDVR SRTSVQTEDD 660
QLIAGQSARA IMAQLPQEEK AKIAEQVEIF HQEKSKLDAE VAKWDDSGND IIVLAKQMCM 720
IMMEMTDFTR GKGPLKNTSD VINAAKKIAE AGSRMDKLAR AVADQCPDSA CKQDLLAYLQ 780
RIALYCHQLN ICSKVKAEVQ NLGGELIVSG LDSATSLIQA AKNLMNAVVL TVKASYVAST 840
KYQKVYGTAA VNSPVVSWKM KAPEKKPLVK REKPEEFQTR VRRGSQKKHI SPVQALSEFK 900
AMDSF 905 
Gene Ontology
 GO:0015629; C:actin cytoskeleton; IEA:InterPro.
 GO:0030424; C:axon; IMP:UniProtKB.
 GO:0016323; C:basolateral plasma membrane; IDA:MGI.
 GO:0005913; C:cell-cell adherens junction; IDA:MGI.
 GO:0005737; C:cytoplasm; ISS:UniProtKB.
 GO:0030027; C:lamellipodium; IDA:MGI.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0007409; P:axonogenesis; IMP:UniProtKB.
 GO:0048854; P:brain morphogenesis; IMP:UniProtKB.
 GO:0016337; P:cell-cell adhesion; ISS:UniProtKB.
 GO:0048813; P:dendrite morphogenesis; IMP:UniProtKB.
 GO:0060134; P:prepulse inhibition; IMP:UniProtKB.
 GO:0021942; P:radial glia guided migration of Purkinje cell; IMP:UniProtKB.
 GO:0051823; P:regulation of synapse structural plasticity; IMP:UniProtKB. 
Interpro
 IPR001033; Alpha_catenin.
 IPR006077; Vinculin/catenin.
 IPR000633; Vinculin_CS. 
Pfam
 PF01044; Vinculin 
SMART
  
PROSITE
 PS00663; VINCULIN_1 
PRINTS
 PR00805; ALPHACATENIN.