UniProt Accession

 RBM39_MOUSE; Q8VH51; Q5RJI0; Q99KV0 

Genbank Protein ID

 AY061882; AK147076; BX649640; AL929404; AL929404; BX649640; CH466551; BC004000; BC030493; BC086645 

Genbank Nucleotide ID

 AAL32373.1; BAE27657.1; CAM13496.1; CAM13496.1; CAM26749.1; CAM26749.1; EDL06184.1; AAH04000.1; AAH30493.1; AAH86645.1 

Protein Name

 RNA-binding protein 39 

Protein Synonyms/Alias

 Coactivator of activating protein 1 and estrogen receptors; Coactivator of AP-1 and ERs; RNA-binding motif protein 39; RNA-binding region-containing protein 2; Transcription coactivator CAPER 

Gene Name

 Rbm39 

Gene Synonyms/Alias

 Caper; Rnpc2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
178	EFFSTVGKVRDVRMI	ubiquitination	[1]
232	VQASQAEKNRAAAMA	ubiquitination	[1]
306	SDSECAKKALEQLNG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1. May be involved in pre-mRNA splicing process. 

Sequence Annotation

 DOMAIN 153 230 RRM 1.
 DOMAIN 250 328 RRM 2.
 DOMAIN 445 508 RRM 3.
 REGION 291 406 Interaction with JUN.
 REGION 291 355 Activating domain.
 REGION 355 406 Interaction with ESR1 and ESR2.
 REGION 406 530 Interaction with NCOA6.
 MOD_RES 2 2 N-acetylalanine (By similarity).
 MOD_RES 95 95 Phosphotyrosine (By similarity).
 MOD_RES 97 97 Phosphoserine.
 MOD_RES 100 100 Phosphoserine (By similarity).
 MOD_RES 136 136 Phosphoserine.
 MOD_RES 146 146 Phosphothreonine (By similarity).
 MOD_RES 334 334 Phosphoserine (By similarity).
 MOD_RES 337 337 Phosphoserine.
 MOD_RES 341 341 Phosphoserine (By similarity).  

Keyword

 3D-structure; Acetylation; Activator; Alternative splicing; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 530 AA 

Protein Sequence

Gene Ontology

 GO:0005813; C:centrosome; IEA:Compara.
 GO:0005634; C:nucleus; TAS:MGI.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0003713; F:transcription coactivator activity; TAS:MGI.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; TAS:MGI. 

Interpro

 IPR006509; CC1_SF.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS