| Tag | Content |
|---|
| CPLM ID | CPLM-019962 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Na(+)/H(+) exchange regulatory cofactor NHE-RF4 |
Protein Synonyms/Alias | NHERF-4; Natrium-phosphate cotransporter IIa C-terminal-associated protein 2; Na/Pi cotransporter C-terminal-associated protein 2; NaPi-Cap2; PDZ domain-containing protein 2; PDZ domain-containing protein 3; Sodium-hydrogen exchanger regulatory factor 4 |
Gene Name | Pdzd3 |
Gene Synonyms/Alias | Nherf4; Pdzk2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 210 | VNGASVEKLTYNQLN | ubiquitination | [1] | | 281 | GFLLREEKGLDGRLG | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions (By similarity). |
Sequence Annotation | DOMAIN 49 130 PDZ 1.
DOMAIN 157 235 PDZ 2.
DOMAIN 263 346 PDZ 3.
DOMAIN 394 475 PDZ 4. |
Keyword | Complete proteome; Cytoplasm; Endosome; Membrane; Reference proteome; Repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 498 AA |
Protein Sequence | MEAAADLRDT ALLTLKFKFN PRLGIDNPVL SLAEDQDQSD PWNLHRPRFC LLSKEEEKTF 60
GFHLQQHLGK ADHVVCRVDP GTSAQRQGLR EGDRILAVNN NIVAHEDHAV VVRYIRASGP 120
RVLLTVLAQH VHDVARVLQG SDAFLCPTLP SGVRPRLCHV VKDEGGFGFS VTHGSRGPFW 180
LVLSAGGAAE RAGVPPGARL LEVNGASVEK LTYNQLNRKL WQSGDQVTLL VAGLEVEEQC 240
HQLGMPLAAP LAEGWALPAK PRCLNIEKGP EGFGFLLREE KGLDGRLGQF LWDVDPGLPA 300
DKAGMKAGDR LVAVAGESVD GLGHEETVSR IRAQGSCVSL IVVDPEADRF FSMVRLSPLL 360
FLENTEIAAP PLAETKDLPV EDTVEPSGLA GSCQCFLYPG PGGGYGFRLC CVASGPCLFI 420
SQVTPGGSTA RAGLQVGDTV LEVNGYPVGG DSELDRLQQL TEAEPPLCLK LGARNPQGLE 480
AWISLESGED WTLASELL 498 |
Gene Ontology | GO:0045177; C:apical part of cell; IDA:UniProtKB. GO:0005903; C:brush border; IDA:UniProtKB. GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell. GO:0035003; C:subapical complex; IEA:Compara. GO:0030251; F:guanylate cyclase inhibitor activity; ISS:UniProtKB. |
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PROSITE | |
PRINTS | |