CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004334
UniProt Accession
Genbank Protein ID
 X16476 
Genbank Nucleotide ID
Protein Name
 Potassium voltage-gated channel subfamily B member 1 
Protein Synonyms/Alias
 Delayed rectifier potassium channel 1; DRK1; Voltage-gated potassium channel subunit Kv2.1 
Gene Name
 Kcnb1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
253LRFLSSPKKWKFFKGacetylation[1]
474KNGESIAKKDKVQDNsumoylation[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] SUMO modification of cell surface Kv2.1 potassium channels regulates the activity of rat hippocampal neurons.
 Plant LD, Dowdell EJ, Dementieva IS, Marks JD, Goldstein SA.
 J Gen Physiol. 2011 May;137(5):441-54. [PMID: 21518833] 
Functional Description
 Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. 
Sequence Annotation
 MOTIF 377 382 Selectivity filter (By similarity).
 MOD_RES 12 12 Phosphoserine (By similarity).
 MOD_RES 15 15 Phosphoserine.
 MOD_RES 128 128 Phosphotyrosine; by Src.
 MOD_RES 457 457 Phosphoserine.
 MOD_RES 484 484 Phosphoserine.
 MOD_RES 496 496 Phosphoserine.
 MOD_RES 503 503 Phosphoserine.
 MOD_RES 520 520 Phosphoserine.
 MOD_RES 541 541 Phosphoserine.
 MOD_RES 567 567 Phosphoserine.
 MOD_RES 590 590 Phosphoserine.
 MOD_RES 607 607 Phosphoserine.
 MOD_RES 655 655 Phosphoserine.
 MOD_RES 719 719 Phosphoserine.
 MOD_RES 771 771 Phosphoserine.
 MOD_RES 799 799 Phosphoserine.
 MOD_RES 804 804 Phosphoserine.
 MOD_RES 836 836 Phosphothreonine.  
Keyword
 3D-structure; Complete proteome; Ion channel; Ion transport; Membrane; Phosphoprotein; Potassium; Potassium channel; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 857 AA 
Protein Sequence
MPAGMTKHGS RSTSSLPPEP MEIVRSKACS RRVRLNVGGL AHEVLWRTLD RLPRTRLGKL 60
RDCNTHDSLL QVCDDYSLED NEYFFDRHPG AFTSILNFYR TGRLHMMEEM CALSFSQELD 120
YWGIDEIYLE SCCQARYHQK KEQMNEELKR EAETLREREG EEFDNTCCAE KRKKLWDLLE 180
KPNSSVAAKI LAIISIMFIV LSTIALSLNT LPELQSLDEF GQSTDNPQLA HVEAVCIAWF 240
TMEYLLRFLS SPKKWKFFKG PLNAIDLLAI LPYYVTIFLT ESNKSVLQFQ NVRRVVQIFR 300
IMRILRILKL ARHSTGLQSL GFTLRRSYNE LGLLILFLAM GIMIFSSLVF FAEKDEDDTK 360
FKSIPASFWW ATITMTTVGY GDIYPKTLLG KIVGGLCCIA GVLVIALPIP IIVNNFSEFY 420
KEQKRQEKAI KRREALERAK RNGSIVSMNM KDAFARSIEM MDIVVEKNGE SIAKKDKVQD 480
NHLSPNKWKW TKRALSETSS SKSFETKEQG SPEKARSSSS PQHLNVQQLE DMYSKMAKTQ 540
SQPILNTKEM APQSKPPEEL EMSSMPSPVA PLPARTEGVI DMRSMSSIDS FISCATDFPE 600
ATRFSHSPLA SLSSKAGSST APEVGWRGAL GASGGRLTET NPIPETSRSG FFVESPRSSM 660
KTNNPLKLRA LKVNFVEGDP TPLLPSLGLY HDPLRNRGGA AAAVAGLECA SLLDKPVLSP 720
ESSIYTTASA RTPPRSPEKH TAIAFNFEAG VHHYIDTDTD DEGQLLYSVD SSPPKSLHGS 780
TSPKFSTGAR TEKNHFESSP LPTSPKFLRP NCVYSSEGLT GKGPGAQEKC KLENHTPPDV 840
HMLPGGGAHG STRDQSI 857 
Gene Ontology
 GO:0030425; C:dendrite; IDA:RGD.
 GO:0032590; C:dendrite membrane; IDA:RGD.
 GO:0032809; C:neuronal cell body membrane; IDA:RGD.
 GO:0045211; C:postsynaptic membrane; IDA:RGD.
 GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
 GO:0005251; F:delayed rectifier potassium channel activity; IDA:RGD.
 GO:0015271; F:outward rectifier potassium channel activity; IMP:RGD.
 GO:0051260; P:protein homooligomerization; IEA:InterPro.
 GO:0051259; P:protein oligomerization; IMP:RGD. 
Interpro
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR005821; Ion_trans_dom.
 IPR027359; K_channel_four-helix_dom.
 IPR003091; K_chnl.
 IPR003968; K_chnl_volt-dep_Kv.
 IPR003973; K_chnl_volt-dep_Kv2.
 IPR004350; K_chnl_volt-dep_Kv2.1.
 IPR003131; T1-type_BTB. 
Pfam
 PF00520; Ion_trans
 PF02214; K_tetra
 PF03521; Kv2channel 
SMART
 SM00225; BTB 
PROSITE
  
PRINTS
 PR00169; KCHANNEL.
 PR01514; KV21CHANNEL.
 PR01491; KVCHANNEL.
 PR01495; SHABCHANNEL.