UniProt Accession

 HXK2_MOUSE; O08528 

Genbank Protein ID

 Y11666; Y11667; Y11668; AJ238540; BC054472 

Genbank Nucleotide ID

 CAA72366.1; CAA72366.1; CAA72366.1; CAB72257.1; AAH54472.1 

Protein Name

 Hexokinase-2 

Protein Synonyms/Alias

 Hexokinase type II; HK II 

Gene Name

 Hk2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
451	RSEDGSGKGAAMVTA	ubiquitination	[1]
488	HEQLLEVKRRMKVEM	ubiquitination	[1]
738	ELSLNPGKQRFEKMI	ubiquitination	[1]
763	NILIDFTKRGLLFRG	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

  

Sequence Annotation

 NP_BIND 84 89 ATP 1 (Potential).
 NP_BIND 425 426 ATP 1 (By similarity).
 NP_BIND 532 537 ATP 2 (By similarity).
 NP_BIND 747 748 ATP 2 (By similarity).
 NP_BIND 784 788 ATP 2 (By similarity).
 NP_BIND 863 867 ATP 2 (By similarity).
 REGION 1 12 Hydrophobic.
 REGION 13 475 Regulatory.
 REGION 84 88 Glucose-6-phosphate 1 binding (By
 REGION 155 156 Substrate 1 binding (By similarity).
 REGION 172 173 Substrate 1 binding (By similarity).
 REGION 208 209 Substrate 1 binding (By similarity).
 REGION 291 294 Substrate 1 binding (By similarity).
 REGION 413 415 Glucose-6-phosphate 1 binding (By
 REGION 476 917 Catalytic.
 REGION 532 536 Glucose-6-phosphate 2 binding (By
 REGION 603 604 Substrate 2 binding (By similarity).
 REGION 620 621 Substrate 2 binding (By similarity).
 REGION 656 657 Substrate 2 binding (By similarity).
 REGION 739 742 Substrate 2 binding (By similarity).
 REGION 861 863 Glucose-6-phosphate 2 binding (By
 BINDING 30 30 ATP 1 (By similarity).
 BINDING 209 209 Glucose-6-phosphate 1 (By similarity).
 BINDING 232 232 Glucose-6-phosphate 1 (By similarity).
 BINDING 235 235 Substrate 1 (By similarity).
 BINDING 260 260 Substrate 1 (By similarity).
 BINDING 449 449 Glucose-6-phosphate 1 (By similarity).
 BINDING 558 558 ATP 2 (Potential).
 BINDING 657 657 Glucose-6-phosphate 2 (By similarity).
 BINDING 680 680 ATP 2 (By similarity).
 BINDING 680 680 Glucose-6-phosphate 2 (By similarity).
 BINDING 683 683 Substrate 2 (By similarity).
 BINDING 708 708 Substrate 2 (By similarity).
 BINDING 897 897 Glucose-6-phosphate 2 (By similarity).
 MOD_RES 461 461 Phosphotyrosine.  

Keyword

 Allosteric enzyme; ATP-binding; Complete proteome; Glycolysis; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Repeat; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 917 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IBA:RefGenome.
 GO:0005741; C:mitochondrial outer membrane; IEA:Compara.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0008865; F:fructokinase activity; IBA:RefGenome.
 GO:0004340; F:glucokinase activity; IBA:RefGenome.
 GO:0005536; F:glucose binding; IEA:Compara.
 GO:0019158; F:mannokinase activity; IBA:RefGenome.
 GO:0008637; P:apoptotic mitochondrial changes; IGI:MGI.
 GO:0001678; P:cellular glucose homeostasis; IBA:RefGenome.
 GO:0006096; P:glycolysis; IBA:RefGenome.
 GO:0007595; P:lactation; IEA:Compara.
 GO:0046324; P:regulation of glucose import; IMP:MGI. 

Interpro

 IPR001312; Hexokinase.
 IPR022673; Hexokinase_C.
 IPR019807; Hexokinase_CS.
 IPR022672; Hexokinase_N. 

Pfam

 PF00349; Hexokinase_1
 PF03727; Hexokinase_2 

SMART

  

PROSITE

 PS00378; HEXOKINASES 

PRINTS

 PR00475; HEXOKINASE.