CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010458
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 T-complex protein 1 subunit zeta 
Protein Synonyms/Alias
 TCP-1-zeta; CCT-zeta-1 
Gene Name
 Cct6a 
Gene Synonyms/Alias
 Cct6; Cctz; Cctz1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
10AVKTLNPKAEVARAQubiquitination[1]
127TEGFEAAKEKALQFLubiquitination[1]
129GFEAAKEKALQFLEQubiquitination[1]
138LQFLEQVKVSKEMDRubiquitination[1]
199EIMEMKHKSETDTSLubiquitination[1]
251VNSGFFYKSAEEREKubiquitination[1]
287KVCGDSDKGFVVINQacetylation[2]
295GFVVINQKGIDPFSLubiquitination[1]
307FSLDALAKEGIVALRubiquitination[1]
365EKFTFIEKCNNPRSVubiquitination[1]
377RSVTLLVKGPNKHTLubiquitination[1]
530RAGMSSLKG******ubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 
Functional Description
 Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. 
Sequence Annotation
 MOD_RES 199 199 N6-acetyllysine (By similarity).
 MOD_RES 365 365 N6-acetyllysine (By similarity).
 MOD_RES 377 377 N6-acetyllysine (By similarity).
 MOD_RES 388 388 N6-acetyllysine (By similarity).  
Keyword
 Acetylation; ATP-binding; Chaperone; Complete proteome; Cytoplasm; Direct protein sequencing; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 531 AA 
Protein Sequence
MAAVKTLNPK AEVARAQAAL AVNISAARGL QDVLRTNLGP KGTMKMLVSG AGDIKLTKDG 60
NVLLHEMQIQ HPTASLIAKV ATAQDDITGD GTTSNVLIIG ELLKQADLYI SEGLHPRIIT 120
EGFEAAKEKA LQFLEQVKVS KEMDRETLID VARTSLRTKV HAELADVLTE AVVDSILAIR 180
KKDEPIDLFM VEIMEMKHKS ETDTSLIRGL VLDHGARHPD MKKRVENAYI LTCNVSLEYE 240
KTEVNSGFFY KSAEEREKLV KAERKFIEDR VKKIIELKKK VCGDSDKGFV VINQKGIDPF 300
SLDALAKEGI VALRRAKRRN MERLTLACGG IALNSFDDLN PDCLGHAGLV YEYTLGEEKF 360
TFIEKCNNPR SVTLLVKGPN KHTLTQIKDA IRDGLRAVKN AIDDGCVVPG AGAVEVALAE 420
ALIKYKPSVK GRAQLGVQAF ADALLIIPKV LAQNSGFDLQ ETLVKVQAEH SESGQLVGVD 480
LSTGEPMVAA EMGVWDNYCV KKQLLHSCTV IATNILLVDE IMRAGMSSLK G 531 
Gene Ontology
 GO:0001669; C:acrosomal vesicle; IDA:MGI.
 GO:0044297; C:cell body; IDA:MGI.
 GO:0005832; C:chaperonin-containing T-complex; IDA:MGI.
 GO:0002199; C:zona pellucida receptor complex; IDA:MGI.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0007339; P:binding of sperm to zona pellucida; IDA:MGI.
 GO:0006457; P:protein folding; IEA:InterPro. 
Interpro
 IPR012722; Chap_CCT_zeta.
 IPR017998; Chaperone_TCP-1.
 IPR002194; Chaperonin_TCP-1_CS.
 IPR002423; Cpn60/TCP-1.
 IPR027409; GroEL-like_apical_dom.
 IPR027413; GROEL-like_equatorial.
 IPR027410; TCP-1-like_intermed. 
Pfam
 PF00118; Cpn60_TCP1 
SMART
  
PROSITE
 PS00750; TCP1_1
 PS00751; TCP1_2
 PS00995; TCP1_3 
PRINTS
 PR00304; TCOMPLEXTCP1.