| Tag | Content |
|---|
| CPLM ID | CPLM-017648 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | PH and SEC7 domain-containing protein 4 |
Protein Synonyms/Alias | Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B; Exchange factor for ARF6 B; Pleckstrin homology and SEC7 domain-containing protein 4; Telomeric of interleukin-1 cluster protein |
Gene Name | PSD4 |
Gene Synonyms/Alias | EFA6B; TIC |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 586 | ANGVRNNKVAWNLAS | ubiquitination | [1] | | 603 | YRLEGFRKSEVAAYL | ubiquitination | [1] | | 764 | LPAGKMSKPFLQLAQ | ubiquitination | [1] | | 779 | DPTVPTYKQGILARK | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5- bisphosphate and phosphatidylinositol 4,5-bisphosphate. |
Sequence Annotation | DOMAIN 544 736 SEC7.
DOMAIN 776 892 PH.
MOD_RES 491 491 Phosphoserine. |
Keyword | Alternative splicing; Cell membrane; Coiled coil; Complete proteome; Guanine-nucleotide releasing factor; Lipid-binding; Membrane; Phosphoprotein; Polymorphism; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1056 AA |
Protein Sequence | MMGDYRLPDH PQPMEILNLY LGDSLEPHPG ECPRETCSHE DPPEPFEEQT WATDPPEPTR 60
QNVPPWGSGV ELTHLGSWVH QDGLEPCQEQ TRATDPPEST RQDAPPWGSG VELTHLGSPS 120
AQREHRQNTA SPGSPVNSHL PGSPKQNRST STQVVFWAGI LQAQMCVLDL EEELEKTEGL 180
KAGLKCCLPT PPVDLPGDTG LHSSPPENED SGEDSSEPEG EGQAWLREGT PDSSPQWGAE 240
EESMFFSNPL FLASPCSENS ASGECFSWGA SDSHAGVRTG PESPATLEPP LPEDTVLWEL 300
ESEPDLGDGA AISGHCTPPF PVPIYKPHSI CWASVAAAEG APAAPPGHGE SEGDRLGPAP 360
SAAPCVDEAL TWESGCVGSD LGPAAHPVQP WASLSPEGWQ RGGPFWPQVT LNSQDRDERE 420
GGHPQESLPC TLAPCPWRSP ASSPEPSSPE SESRGPGPRP SPASSQEGSP QLQHHSSGIL 480
PKWTLDASQS SLLETDGEQP SSLKKKEAGE APKPGEEVKS EGTARPAETG DVQPDIHLTS 540
AEHENLRTPM NSSWLPGSPM PQAQSPEEGQ RPPAGDKLAN GVRNNKVAWN LASRLYRLEG 600
FRKSEVAAYL QKNNDFSRAV AEEYLSFFQF GGQSLDRALR SFLQALVLSG ETQERERILY 660
QFSRRFHHCN PGIFPSVDSV HTLTCAIMLL NTDLHGQNIG KSMSCQEFIT NLNGLRDGGN 720
FPKELLKALY WSIRSEKLEW AVDEEDTARP EKAQPSLPAG KMSKPFLQLA QDPTVPTYKQ 780
GILARKMHQD ADGKKTPWGK RGWKMFHTLL RGMVLYFLKQ GEDHCLEGES LVGQMVDEPV 840
GVHHSLATPA THYTKKPHVF QLRTADWRLY LFQAPTAKEM SSWIARINLA AATHSAPPFP 900
AAVGSQRRFV RPILPVGPAQ SSLEEQHRSH ENCLDAAADD LLDLQRNLPE RRGRGRELEE 960
HRLRKEYLEY EKTRYETYVQ LLVARLHCPS DALDLWEEQL GREAGGTREP KLSLKKSHSS 1020
PSLHQDEAPT TAKVKRNISE RRTYRKIIPK RNRNQL 1056 |
Gene Ontology | GO:0030054; C:cell junction; IBA:RefGenome. GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. GO:0005086; F:ARF guanyl-nucleotide exchange factor activity; IBA:RefGenome. GO:0005543; F:phospholipid binding; IEA:InterPro. GO:0030182; P:neuron differentiation; IBA:RefGenome. GO:0032012; P:regulation of ARF protein signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |