UniProt Accession

 NUCL_RAT; P13383 

Genbank Protein ID

 M55022; M55015; M55017; M55020; M22090 

Genbank Nucleotide ID

 AAA41732.1; AAA41732.1; AAA41732.1; AAA41732.1; AAA41733.1 

Protein Name

 Nucleolin 

Protein Synonyms/Alias

 Protein C23 

Gene Name

 Ncl 

Gene Synonyms/Alias

 Nuc 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
87	KAAVTPGKKAAATPA	acetylation	[1]
116	KKGAAQAKALVPTPG	acetylation	[1]
124	ALVPTPGKKGAVTPA	acetylation	[1]
135	VTPAKGAKNGKNAKK	acetylation	[1]
627	FNSEEDAKAAKEAME	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Nucleolin is the major nucleolar protein of growing eukaryotic cells. It is found associated with intranucleolar chromatin and pre-ribosomal particles. It induces chromatin decondensation by binding to histone H1. It is thought to play a role in pre-rRNA transcription and ribosome assembly. May play a role in the process of transcriptional elongation. Binds RNA oligonucleotides with 5'-UUAGGG-3' repeats more tightly than the telomeric single-stranded DNA 5'-TTAGGG-3' repeats (By similarity). 

Sequence Annotation

 REPEAT 58 65 1.
 REPEAT 75 82 2.
 REPEAT 83 90 3.
 REPEAT 91 98 4.
 REPEAT 99 104 5; truncated.
 REPEAT 105 112 6.
 REPEAT 120 127 7.
 REPEAT 128 135 8.
 DOMAIN 311 387 RRM 1.
 DOMAIN 397 470 RRM 2.
 DOMAIN 489 563 RRM 3.
 DOMAIN 575 650 RRM 4.
 REGION 58 135 8 X 8 AA tandem repeats of X-T-P-X-K-K-X-
 MOD_RES 9 9 N6-acetyllysine (By similarity).
 MOD_RES 15 15 N6-acetyllysine (By similarity).
 MOD_RES 28 28 Phosphoserine (By similarity).
 MOD_RES 34 34 Phosphoserine (By similarity).
 MOD_RES 40 40 Phosphoserine (By similarity).
 MOD_RES 41 41 Phosphoserine (By similarity).
 MOD_RES 67 67 Phosphoserine (By similarity).
 MOD_RES 69 69 Phosphothreonine (By similarity).
 MOD_RES 76 76 Phosphothreonine (By similarity).
 MOD_RES 84 84 Phosphothreonine (By similarity).
 MOD_RES 92 92 Phosphothreonine (By similarity).
 MOD_RES 99 99 Phosphothreonine (By similarity).
 MOD_RES 102 102 N6-acetyllysine (By similarity).
 MOD_RES 106 106 Phosphothreonine (By similarity).
 MOD_RES 116 116 N6-acetyllysine (By similarity).
 MOD_RES 121 121 Phosphothreonine (By similarity).
 MOD_RES 124 124 N6-acetyllysine (By similarity).
 MOD_RES 145 145 Phosphoserine.
 MOD_RES 157 157 Phosphoserine.
 MOD_RES 187 187 Phosphoserine (By similarity).
 MOD_RES 213 213 Phosphoserine (By similarity).
 MOD_RES 221 221 Phosphothreonine (By similarity).
 MOD_RES 308 308 Phosphothreonine (By similarity).
 MOD_RES 309 309 Phosphothreonine (By similarity).
 MOD_RES 322 322 N6-acetyllysine (By similarity).
 MOD_RES 381 381 N6-acetyllysine (By similarity).
 MOD_RES 402 402 N6-acetyllysine (By similarity).
 MOD_RES 516 516 N6-acetyllysine (By similarity).
 MOD_RES 566 566 Phosphoserine (By similarity).
 MOD_RES 575 575 N6-acetyllysine (By similarity).
 MOD_RES 580 580 N6-acetyllysine (By similarity).
 MOD_RES 583 583 Phosphoserine (By similarity).
 MOD_RES 622 622 Phosphoserine (By similarity).
 MOD_RES 649 649 N6-acetyllysine (By similarity).
 MOD_RES 659 659 Asymmetric dimethylarginine (By
 MOD_RES 663 663 Asymmetric dimethylarginine (By
 MOD_RES 669 669 Asymmetric dimethylarginine (By
 MOD_RES 673 673 Asymmetric dimethylarginine (By
 MOD_RES 676 676 Asymmetric dimethylarginine (By  

Keyword

 Acetylation; Complete proteome; Cytoplasm; DNA-binding; Methylation; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 713 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
 GO:0030529; C:ribonucleoprotein complex; ISS:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; ISS:UniProtKB.
 GO:0042162; F:telomeric DNA binding; ISS:UniProtKB. 

Interpro

 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 

Pfam

 PF00076; RRM_1 

SMART

 SM00360; RRM 

PROSITE

 PS50102; RRM 

PRINTS