CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033051
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Replication initiator 1 
Protein Synonyms/Alias
  
Gene Name
 REPIN1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
90ESPQTLGKESRGLRQacetylation[1, 2, 3]
90ESPQTLGKESRGLRQubiquitination[3, 4]
Reference
 [1] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 624 AA 
Protein Sequence
MGIGVSLLLQ FSLTPGGYRS VGRSRRCSRG SIPRNIPKRS WKKPHPQLCS LQAEEEPMLE 60
RRCRGPLAMG LAQPRLLSGP SQESPQTLGK ESRGLRQQGT SVAQSGAQAP GRAHRCAHCR 120
RHFPGWVALW LHTRRCQARL PLPCPECGRR FRHAPFLALH RQVHAAATPD LGFACHLCGQ 180
SFRGWVALVL HLRAHSAAKR PIACPKCERR FWRRKQLRAH LRRCHPPAPE ARPFICGNCG 240
RSFAQWDQLV AHKRVHVAEA LEEAAAKALG PRPRGRPAVT APRPGGDAVD RPFQCACCGK 300
RFRHKPNLIA HRRVHTGERP HQCPECGKRF TNKPYLTSHR RIHTGEKPYP CKECGRRFRH 360
KPNLLSHSKI HKRSEGSAQA APGPGSPQLP AGPQESAAEP TPAVPLKPAQ EPPPGAPPEH 420
PQDPIEAPPS LYSCDDCGRS FRLERFLRAH QRQHTGERPF TCAECGKNFG KKTHLVAHSR 480
VHSGERPFAC EECGRRFSQG SHLAAHRRDH APDRPFVCPD CGKAFRHKPY LAAHRRIHTG 540
EKPYVCPDCG KAFSQKSNLV SHRRIHTGER PYACPDCDRS FSQKSNLITH RKSHIRDGAF 600
CCAICGQTFD DEERLLAHQK KHDV 624 
Gene Ontology
 GO:0022626; C:cytosolic ribosome; IEA:Compara.
 GO:0005811; C:lipid particle; IEA:Compara.
 GO:0031965; C:nuclear membrane; IEA:Compara.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:2000191; P:regulation of fatty acid transport; IEA:Compara.
 GO:2001273; P:regulation of glucose import in response to insulin stimulus; IEA:Compara. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
 PF00096; zf-C2H2 
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS