CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009693
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Potassium voltage-gated channel subfamily A member 2 
Protein Synonyms/Alias
 RAK; RBK2; RCK5; Voltage-gated potassium channel subunit Kv1.2 
Gene Name
 Kcna2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
49LRFETQLKTLAQFPEacetylation[1]
63ETLLGDPKKRMRYFDubiquitination[2]
64TLLGDPKKRMRYFDPubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. 
Sequence Annotation
 MOTIF 374 379 Selectivity filter.
 MOTIF 497 499 PDZ-binding.
 MOD_RES 421 421 Phosphothreonine (By similarity).
 MOD_RES 429 429 Phosphotyrosine (By similarity).
 MOD_RES 433 433 Phosphothreonine (By similarity).
 MOD_RES 449 449 Phosphoserine; by PKA (Potential).
 LIPID 244 244 S-palmitoyl cysteine (Potential).
 CARBOHYD 38 38 N-linked (GlcNAc...) (Potential).
 CARBOHYD 207 207 N-linked (GlcNAc...) (Potential).  
Keyword
 3D-structure; Complete proteome; Glycoprotein; Ion channel; Ion transport; Lipoprotein; Membrane; Palmitate; Phosphoprotein; Potassium; Potassium channel; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 499 AA 
Protein Sequence
MTVATGDPVD EAAALPGHPQ DTYDPEADHE CCERVVINIS GLRFETQLKT LAQFPETLLG 60
DPKKRMRYFD PLRNEYFFDR NRPSFDAILY YYQSGGRLRR PVNVPLDIFS EEIRFYELGE 120
EAMEMFREDE GYIKEEERPL PENEFQRQVW LLFEYPESSG PARIIAIVSV MVILISIVSF 180
CLETLPIFRD ENEDMHGGGV TFHTYSNSTI GYQQSTSFTD PFFIVETLCI IWFSFEFLVR 240
FFACPSKAGF FTNIMNIIDI VAIIPYFITL GTELAEKPED AQQGQQAMSL AILRVIRLVR 300
VFRIFKLSRH SKGLQILGQT LKASMRELGL LIFFLFIGVI LFSSAVYFAE ADERDSQFPS 360
IPDAFWWAVV SMTTVGYGDM VPTTIGGKIV GSLCAIAGVL TIALPVPVIV SNFNYFYHRE 420
TEGEEQAQYL QVTSCPKIPS SPDLKKSRSA STISKSDYME IQEGVNNSNE DFREENLKTA 480
NCTLANTNYV NITKMLTDV 499 
Gene Ontology
 GO:0044224; C:juxtaparanode region of axon; IDA:BHF-UCL.
 GO:0008076; C:voltage-gated potassium channel complex; IEA:Compara.
 GO:0005251; F:delayed rectifier potassium channel activity; IBA:RefGenome.
 GO:0015271; F:outward rectifier potassium channel activity; IMP:RGD.
 GO:0021633; P:optic nerve structural organization; IEA:Compara.
 GO:0051260; P:protein homooligomerization; IEA:InterPro.
 GO:0051259; P:protein oligomerization; IMP:RGD. 
Interpro
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR005821; Ion_trans_dom.
 IPR027359; K_channel_four-helix_dom.
 IPR003091; K_chnl.
 IPR003968; K_chnl_volt-dep_Kv.
 IPR003972; K_chnl_volt-dep_Kv1.
 IPR004049; K_chnl_volt-dep_Kv1.2.
 IPR003131; T1-type_BTB. 
Pfam
 PF00520; Ion_trans
 PF02214; K_tetra 
SMART
 SM00225; BTB 
PROSITE
  
PRINTS
 PR00169; KCHANNEL.
 PR01509; KV12CHANNEL.
 PR01491; KVCHANNEL.
 PR01496; SHAKERCHANEL.