CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031689
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Atlastin-2 
Protein Synonyms/Alias
  
Gene Name
 ATL2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
94GGKQFLEKRLQVKQNubiquitination[1]
99LEKRLQVKQNQHEELubiquitination[1, 2, 3]
143PSFDGRLKDIDEDFKubiquitination[1, 2, 3]
150KDIDEDFKRELRNLVubiquitination[1, 2, 4]
169APENLVEKEISGSKVubiquitination[1]
175EKEISGSKVTCRDLVubiquitination[1]
190EYFKAYIKIYQGEELubiquitination[1, 2, 4, 5, 6]
201GEELPHPKSMLQATAubiquitination[1, 2, 4, 6]
225GARDTYCKSMEQVCGubiquitination[1, 4]
251ERKHLDLKEVAIKQFubiquitination[2]
256DLKEVAIKQFRSVKKubiquitination[1]
290ETYANFIKHNDGKNIubiquitination[2, 4, 6]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [6] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 413 AA 
Protein Sequence
MDTQGAFDSQ STIKDCATVF ALSTMTSSVQ VYNLSQNIQE DDLQHLQLFT EYGRLAMEEI 60
YQKPFQTLMF LIRDWSYPYE HSYGLEGGKQ FLEKRLQVKQ NQHEELQNVR KHIHNCFSNL 120
GCFLLPHPGL KVATNPSFDG RLKDIDEDFK RELRNLVPLL LAPENLVEKE ISGSKVTCRD 180
LVEYFKAYIK IYQGEELPHP KSMLQATAEA NNLAAVAGAR DTYCKSMEQV CGGDKPYIAP 240
SDLERKHLDL KEVAIKQFRS VKKMGGDEFC RRYQDQLEAE IEETYANFIK HNDGKNIFYA 300
ARTPATLFAV MFAMYIISGL TGFIGLNSIA VLCNLVMGLA LIFLCTWAYV KYSGEFREIG 360
TVIDQIAETL WEQRSPRKVF SKLFEVTRRR MVHRALSSAQ RQRLSSNNNK KKN 413 
Gene Ontology
 GO:0005525; F:GTP binding; IEA:InterPro.
 GO:0003924; F:GTPase activity; IEA:InterPro.
 GO:0006184; P:GTP catabolic process; IEA:GOC. 
Interpro
 IPR003191; Guanylate-bd_C.
 IPR015894; Guanylate-bd_N.
 IPR027417; P-loop_NTPase. 
Pfam
 PF02263; GBP
 PF02841; GBP_C 
SMART
  
PROSITE
  
PRINTS