| Tag | Content |
|---|
| CPLM ID | CPLM-005422 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Mediator of replication checkpoint protein 1 |
Protein Synonyms/Alias | DNA replication checkpoint mediator MRC1 |
Gene Name | MRC1 |
Gene Synonyms/Alias | YCL061C; YCL61C/YCL60C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 116 | KDNSYSEKNVSSSFT | acetylation | [1] | | 426 | MDSIKLSKDESVLPI | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Required for normal DNA replication. Phosphorylated in response to DNA replication stress. Phosphorylation allows it to mediate the activation of RAD53. |
Sequence Annotation | MOD_RES 144 144 Phosphoserine.
MOD_RES 409 409 Phosphoserine.
MOD_RES 411 411 Phosphoserine.
MOD_RES 434 434 Phosphoserine.
MOD_RES 605 605 Phosphoserine.
MOD_RES 607 607 Phosphoserine.
MOD_RES 801 801 Phosphoserine.
MOD_RES 807 807 Phosphoserine.
MOD_RES 911 911 Phosphoserine. |
Keyword | Coiled coil; Complete proteome; DNA replication; Nucleus; Phosphoprotein; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1096 AA |
Protein Sequence | MDDALHALSS LTAKKRTTTY KKVAVPILDE NDNTNGNGPN DIDNPPELTG NGFLFANATL 60
NRVKNRLEGK KAPEQNHNNG KDRSENSLPT QLISNLYDGG EELEKSEVKD NSYSEKNVSS 120
SFTQTQRIPV SIQQDKVFNV PIHSVNDGKP TQLIKEDGLV NETSQALKTP LTTGRPGATQ 180
RIDSSGATSQ TQPIKSIEPQ SQIITTSSNH SNALSPKIPI IPTELIGTSP LFQSIQNRGP 240
DTQMDVPPQT AHDEDKTQAI GIPQATHQEQ KTQIDTVAQT LQDEVPHTLK IREIQSELAS 300
EDSKREKARN VEYKKPQKPI PTKKFFSKES FLADFDDSSS NEDDDIKLEN AHPKPVQNDD 360
ELHENKSVEL NLTDETRINE KRVPLLSSYA NNLKREIDSS KCITLDLDSD SDEYGDDDMD 420
SIKLSKDESV LPISQLSKAT ILNLKARLSK QNQKLSQRPN KSKDPKVDHN VLLNTLRKAS 480
RKQILDHQKE VIETKGLKLE DMAKEKEIVE NLLEQEILRN KRIRQKEKRR EKLEENDFQL 540
NAHDSGSDSG SESSGFALSG NEIADYESSG SENDNRRESD SEKEDDEIIL KQKKSHHVKH 600
IINESDSDTE VEAKPKEKAD ESLPKRIAIN LGHYGDNIGE DTDKFQETNV LDTQNIEEVM 660
AERNTIENEV KDDVYVNEEA DEAIRRQLID KEKLQLKQKE KEHEAKIKEL KKRGVTNFFE 720
MEAEESEDEW HGIGGADGEG SDDYDSDLEK MIDDYSKNNF NPHEIREMLA AENKEMDIKM 780
INKILYDIKN GGFRNKRAKN SLELELSDDD EDDVLQQYRL KRRELMRKRR LEIGDDAKLV 840
KNPKSSAFFE SMVEDIIEYK NPFGAEEEYN LDITSTATDL DTQDNSINVG DNTGNNEQKP 900
VDQKNKKVII SEDFVQKSLS FLKSNNYEDF ETDKELSRIQ HGNDEAIEDL YTLKQNSSIK 960
SFTNSQTDST TSKTVNTIID LEKRPEDEDE VENGDTSLVG VFKHPSIIKS FASRTDINDK 1020
FKEGNKTVKI LKSYKTVGSS KASITYMGKT RKLIAPKRKT EGSHRYHHDH HNKKMKMKTK 1080
TKSNKLFESG QDSFDN 1096 |
Gene Ontology | GO:0031298; C:replication fork protection complex; IDA:SGD. GO:0030466; P:chromatin silencing at silent mating-type cassette; IMP:SGD. GO:0006348; P:chromatin silencing at telomere; IMP:SGD. GO:0006281; P:DNA repair; IMP:SGD. GO:0000076; P:DNA replication checkpoint; IMP:SGD. GO:0031573; P:intra-S DNA damage checkpoint; IMP:SGD. GO:0043570; P:maintenance of DNA repeat elements; IMP:SGD. GO:0007064; P:mitotic sister chromatid cohesion; IMP:SGD. GO:0048478; P:replication fork protection; IMP:SGD. GO:0000723; P:telomere maintenance; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |