UniProt Accession

 FUR_ECOLI; P0A9A9; P06975 

Genbank Protein ID

 X02589; U00096; AP009048 

Genbank Nucleotide ID

 CAA26429.1; AAC73777.1; BAA35331.1 

Protein Name

 Ferric uptake regulation protein 

Protein Synonyms/Alias

 Ferric uptake regulator 

Gene Name

 fur 

Gene Synonyms/Alias

 b0683; JW0669 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
9	TDNNTALKKAGLKVT	acetylation	[1]
10	DNNTALKKAGLKVTL	acetylation	[1]
14	ALKKAGLKVTLPRLK	acetylation	[1]
21	KVTLPRLKILEVLQE	acetylation	[1]
41	VSAEDLYKRLIDMGE	acetylation	[1]
117	RQREIAAKHGIRLTN	acetylation	[2]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Comprehensive profiling of protein lysine acetylation in Escherichia coli.
 Zhang K, Zheng S, Yang JS, Chen Y, Cheng Z.
 J Proteome Res. 2013 Feb 1;12(2):844-51. [PMID: 23294111] 

Functional Description

 Acts as a global negative controlling element, employing Fe(2+) as a cofactor to bind the operator of the repressed genes. Regulates the expression of several outer-membrane proteins including the iron transport operon. 

Sequence Annotation

 REGION 2 84 DNA-binding (By similarity).
 REGION 85 148 Dimerization (By similarity).
 METAL 33 33 Zinc (By similarity).
 METAL 81 81 Zinc (By similarity).
 METAL 87 87 Iron (By similarity).
 METAL 89 89 Iron (By similarity).
 METAL 90 90 Zinc (By similarity).
 METAL 93 93 Zinc.
 METAL 96 96 Zinc.
 METAL 101 101 Zinc (By similarity).
 METAL 108 108 Iron (By similarity).
 METAL 125 125 Iron (By similarity).  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Direct protein sequencing; DNA-binding; Iron; Metal-binding; Reference proteome; Repressor; Transcription; Transcription regulation; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 148 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IDA:EcoliWiki.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR002481; FUR.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF01475; FUR 

SMART

  

PROSITE

  

PRINTS