CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043687
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 High mobility group protein HMG-I/HMG-Y 
Protein Synonyms/Alias
  
Gene Name
 HMGA1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
7*MSESSSKSSQPLASubiquitination[1]
15SSQPLASKQEKDGTEacetylation[2, 3, 4, 5]
15SSQPLASKQEKDGTEubiquitination[5, 6]
31RGRGRPRKQPPVSPGacetylation[2]
31RGRGRPRKQPPVSPGubiquitination[6]
46TALVGSQKEPSEVPTubiquitination[1, 5, 6]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Monoclonal antibody cocktail as an enrichment tool for acetylome analysis.
 Shaw PG, Chaerkady R, Zhang Z, Davidson NE, Pandey A.
 Anal Chem. 2011 May 15;83(10):3623-6. [PMID: 21466224]
 [3] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 328 AA 
Protein Sequence
MSESSSKSSQ PLASKQEKDG TEKRGRGRPR KQPPVSPGTA LVGSQKEPSE VPTPKRPRGR 60
PKGSKNKGEG GRGGHLAGVL GGGAVTHACR LLLTGGAASF WDWTALLRSH RPHPFPRPTI 120
TTASGRHPHL PPVPSPPHYT AHQPLQGSHG LSGEQFSPGL SSQLPPPTHA YTHALLDKAN 180
IPLSRTLHLL RPHSLGGGDI ALWAFGLGAP SLLLHCSLWL PIVGPGRVPL ALKGAQAPSH 240
PGTPYSTALA AAGVANGGGC WPPGFPQPNC LCHHVGLTFH PSPTSLVPVL GWTAPFGYRK 300
AGGVSPLLPL HCGHSPLALR LGSEYILW 328 
Gene Ontology
 GO:0000785; C:chromatin; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:InterPro. 
Interpro
 IPR020478; AT_hook-like.
 IPR017956; AT_hook_DNA-bd_motif.
 IPR000116; HMGI/HMGY.
 IPR000637; HMGI/Y_DNA-bd_CS. 
Pfam
  
SMART
 SM00384; AT_hook 
PROSITE
 PS00354; HMGI_Y 
PRINTS
 PR00929; ATHOOK.
 PR00930; HIGHMOBLTYIY.