UniProt Accession

 FIS1_HUMAN; Q9Y3D6; Q9BTP3 

Genbank Protein ID

 AF151893; AC006329; BC003540; BC009428 

Genbank Nucleotide ID

 AAD34130.1; AAP22366.1; AAH03540.1; AAH09428.1 

Protein Name

 Mitochondrial fission 1 protein 

Protein Synonyms/Alias

 FIS1 homolog; hFis1; Tetratricopeptide repeat protein 11; TPR repeat protein 11 

Gene Name

 FIS1 

Gene Synonyms/Alias

 TTC11; CGI-135 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
20	DLLKFEKKFQSEKAA	ubiquitination	[1]
25	EKKFQSEKAAGSVSK	ubiquitination	[1]
53	KYNDDIRKGIVLLEE	ubiquitination	[1, 2, 3, 4]

Reference

 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [3] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission. 

Sequence Annotation

 REPEAT 71 104 TPR.
 MOD_RES 1 1 N-acetylmethionine.  

Keyword

 3D-structure; Acetylation; Apoptosis; Complete proteome; Direct protein sequencing; Membrane; Mitochondrion; Mitochondrion outer membrane; Peroxisome; Reference proteome; TPR repeat; Transmembrane; Transmembrane helix; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 152 AA 

Protein Sequence

Gene Ontology

 GO:0031307; C:integral to mitochondrial outer membrane; IDA:UniProtKB.
 GO:0005779; C:integral to peroxisomal membrane; IDA:UniProtKB.
 GO:0043234; C:protein complex; IDA:UniProtKB.
 GO:0035584; P:calcium-mediated signaling using intracellular calcium source; IMP:UniProtKB.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IMP:UniProtKB.
 GO:0051561; P:elevation of mitochondrial calcium ion concentration; IMP:UniProtKB.
 GO:0043653; P:mitochondrial fragmentation involved in apoptotic process; IDA:UniProtKB.
 GO:0000422; P:mitochondrion degradation; IDA:UniProtKB.
 GO:0070584; P:mitochondrion morphogenesis; IMP:UniProtKB.
 GO:0016559; P:peroxisome fission; IDA:UniProtKB.
 GO:0043280; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; IMP:UniProtKB.
 GO:2001244; P:positive regulation of intrinsic apoptotic signaling pathway; IMP:UniProtKB.
 GO:0051260; P:protein homooligomerization; IMP:UniProtKB.
 GO:0006626; P:protein targeting to mitochondrion; IMP:UniProtKB.
 GO:0032471; P:reduction of endoplasmic reticulum calcium ion concentration; IMP:UniProtKB.
 GO:0010821; P:regulation of mitochondrion organization; IMP:UniProtKB.
 GO:0001836; P:release of cytochrome c from mitochondria; IMP:UniProtKB. 

Interpro

 IPR016543; Tetratricopeptide_rpt_11_Fis1.
 IPR011990; TPR-like_helical. 

Pfam

  

SMART

  

PROSITE

 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS