CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035305
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Purine nucleoside phosphorylase 
Protein Synonyms/Alias
 Inosine-guanosine phosphorylase 
Gene Name
 Pnp 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
178QKAFNAWKQMGEQREacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity). 
Sequence Annotation
  
Keyword
 Complete proteome; Glycosyltransferase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 288 AA 
Protein Sequence
IPRFTYEDYQ RTAEWLRSHT KHRPQVAVIC GSGLGGLTAK LTQPQAFDYN EIPNFPQSTV 60
QGHAGRLVFG FLNGRSCVMM QGRFHMYEGY SLSKVTFPVR VFHLLGVDTL VVTNAAGGLN 120
PKFEVGDIML IRDHINLPGF CGQNPLRGPN DERFGVRFPA MSDAYDRDMR QKAFNAWKQM 180
GEQRELQEGT YIMSAGPTFE TVAESCLLRM LGADAVGMST VPEVIVARHC GLRVFGFSLI 240
TNKVVMDYNN LEKASHQEVL EAGKAAAQKL EQFVSILMES IPPRERAN 288 
Gene Ontology
 GO:0004731; F:purine-nucleoside phosphorylase activity; IEA:EC.
 GO:0009116; P:nucleoside metabolic process; IEA:InterPro. 
Interpro
 IPR000845; Nucleoside_phosphorylase_d.
 IPR001369; PNP/MTAP.
 IPR011270; Pur_Nuc_Pase_Ino/Guo-sp.
 IPR011268; Purine_phosphorylase.
 IPR018099; Purine_phosphorylase-2_CS. 
Pfam
 PF01048; PNP_UDP_1 
SMART
  
PROSITE
 PS01240; PNP_MTAP_2 
PRINTS