CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-020274
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TRAF-interacting protein 
Protein Synonyms/Alias
 RING finger protein 206 
Gene Name
 TRAIP 
Gene Synonyms/Alias
 RNF206; TRIP 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
140STLKKQMKYLEQQQDubiquitination[1, 2]
150EQQQDETKQAQEEARubiquitination[1, 2]
205AVYCVSLKKEYENLKubiquitination[1]
235DLFSSRSKLQTVYSEubiquitination[2]
269KEIMSLKKKLTMLQEubiquitination[2]
362KICKGPRKESQLSLGubiquitination[2]
397RNAILGQKQPKRPRSubiquitination[2]
410RSESSCSKDVVRTGFubiquitination[2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Inhibits activation of NF-kappa-B mediated by TNF (By similarity). 
Sequence Annotation
 ZN_FING 7 50 RING-type.
 REGION 211 469 Interaction with CYLD.  
Keyword
 Coiled coil; Complete proteome; Cytoplasm; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 469 AA 
Protein Sequence
MPIRALCTIC SDFFDHSRDV AAIHCGHTFH LQCLIQWFET APSRTCPQCR IQVGKRTIIN 60
KLFFDLAQEE ENVLDAEFLK NELDNVRAQL SQKDKEKRDS QVIIDTLRDT LEERNATVVS 120
LQQALGKAEM LCSTLKKQMK YLEQQQDETK QAQEEARRLR SKMKTMEQIE LLLQSQRPEV 180
EEMIRDMGVG QSAVEQLAVY CVSLKKEYEN LKEARKASGE VADKLRKDLF SSRSKLQTVY 240
SELDQAKLEL KSAQKDLQSA DKEIMSLKKK LTMLQETLNL PPVASETVDR LVLESPAPVE 300
VNLKLRRPSF RDDIDLNATF DVDTPPARPS SSQHGYYEKL CLEKSHSPIQ DVPKKICKGP 360
RKESQLSLGG QSCAGEPDEE LVGAFPIFVR NAILGQKQPK RPRSESSCSK DVVRTGFDGL 420
GGRTKFIQPT DTVMIRPLPV KPKTKVKQRV RVKTVPSLFQ AKLDTFLWS 469 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IDA:HPA.
 GO:0005057; F:receptor signaling protein activity; IEA:Compara.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0008283; P:cell proliferation; TAS:ProtInc.
 GO:0006917; P:induction of apoptosis; TAS:ProtInc.
 GO:0007165; P:signal transduction; TAS:ProtInc. 
Interpro
 IPR009053; Prefoldin.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF13639; zf-RING_2 
SMART
 SM00184; RING 
PROSITE
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS