CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017966
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 N-lysine methyltransferase SETD6 
Protein Synonyms/Alias
 SET domain-containing protein 6 
Gene Name
 SETD6 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
39VGLELSPKVSERAGGubiquitination[1]
327EAALQGTKTEAERHLubiquitination[1]
385AEEFRELKDQDGGGDubiquitination[1]
441DQGLLSNKEVYAKLSubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Protein-lysine N-methyltransferase that specifically monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF-kappa-B transcription factor activity. 
Sequence Annotation
 DOMAIN 60 286 SET.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Methyltransferase; Nucleus; Polymorphism; Reference proteome; S-adenosyl-L-methionine; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 473 AA 
Protein Sequence
MATQAKRPRV AGPVDGGDLD PVACFLSWCR RVGLELSPKV SERAGGRRTR GGARAALTSP 60
PAQVAVSRQG TVAGYGMVAR ESVQAGELLF VVPRAALLSQ HTCSIGGLLE RERVALQSQS 120
GWVPLLLALL HELQAPASRW RPYFALWPEL GRLEHPMFWP EEERRCLLQG TGVPEAVEKD 180
LANIRSEYQS IVLPFMEAHP DLFSLRVRSL ELYHQLVALV MAYSFQEPLE EEEDEKEPNS 240
PVMVPAADIL NHLANHNANL EYSANCLRMV ATQPIPKGHE IFNTYGQMAN WQLIHMYGFV 300
EPYPDNTDDT ADIQMVTVRE AALQGTKTEA ERHLVYERWD FLCKLEMVGE EGAFVIGREE 360
VLTEEELTTT LKVLCMPAEE FRELKDQDGG GDDKREEGSL TITNIPKLKA SWRQLLQNSV 420
LLTLQTYATD LKTDQGLLSN KEVYAKLSWR EQQALQVRYG QKMILHQLLE LTS 473 
Gene Ontology
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0016279; F:protein-lysine N-methyltransferase activity; IDA:UniProtKB.
 GO:0032088; P:negative regulation of NF-kappaB transcription factor activity; IMP:UniProtKB.
 GO:0018026; P:peptidyl-lysine monomethylation; IDA:UniProtKB.
 GO:0050727; P:regulation of inflammatory response; IMP:UniProtKB. 
Interpro
 IPR011383; RuBisCo-cyt_methylase.
 IPR015353; Rubisco_LSMT_subst-bd.
 IPR001214; SET_dom. 
Pfam
 PF09273; Rubis-subs-bind
 PF00856; SET 
SMART
 SM00317; SET 
PROSITE
 PS50280; SET 
PRINTS