UniProt Accession

 TBL1R_MOUSE; Q8BHJ5; Q3UWL6; Q8CBG4; Q8VEG3; Q9EQD4 

Genbank Protein ID

 AF268195; AK029595; AK033347; AK036064; AK136255; BC018512 

Genbank Nucleotide ID

 AAG44738.1; BAC26526.1; BAC28241.1; BAC29294.1; BAE22898.1; AAH18512.1 

Protein Name

 F-box-like/WD repeat-containing protein TBL1XR1 

Protein Synonyms/Alias

 Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; TBL1-related protein 1; Transducin beta-like 1X-related protein 1 

Gene Name

 Tbl1xr1 

Gene Synonyms/Alias

 Ira1; Tblr1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
102	RQQAYRDKLAQQHAA	acetylation	[1]
102	RQQAYRDKLAQQHAA	ubiquitination	[2]
277	FALKWNKKGNFILSA	ubiquitination	[2]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation (By similarity). 

Sequence Annotation

 DOMAIN 4 36 LisH.
 DOMAIN 41 86 F-box-like.
 REPEAT 167 206 WD 1.
 REPEAT 223 262 WD 2.
 REPEAT 264 303 WD 3.
 REPEAT 306 344 WD 4.
 REPEAT 347 386 WD 5.
 REPEAT 389 437 WD 6.
 REPEAT 440 479 WD 7.
 REPEAT 481 513 WD 8.  

Keyword

 Activator; Chromatin regulator; Complete proteome; Nucleus; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Ubl conjugation pathway; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 514 AA 

Protein Sequence

Gene Ontology

 GO:0000118; C:histone deacetylase complex; IEA:Compara.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005876; C:spindle microtubule; IEA:Compara.
 GO:0017053; C:transcriptional repressor complex; IEA:Compara.
 GO:0003714; F:transcription corepressor activity; IMP:MGI.
 GO:0044212; F:transcription regulatory region DNA binding; IDA:BHF-UCL.
 GO:0060070; P:canonical Wnt receptor signaling pathway; IEA:Compara.
 GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL.
 GO:0043161; P:proteasomal ubiquitin-dependent protein catabolic process; IMP:MGI.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR020472; G-protein_beta_WD-40_rep.
 IPR006594; LisH_dimerisation.
 IPR013720; LisH_dimerisation_subgr.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF08513; LisH
 PF00400; WD40 

SMART

 SM00667; LisH
 SM00320; WD40 

PROSITE

 PS50896; LISH
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00320; GPROTEINBRPT.