| Tag | Content |
|---|
| CPLM ID | CPLM-021843 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DNA-binding protein Rfx5 |
Protein Synonyms/Alias | Regulatory factor X 5 |
Gene Name | Rfx5 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 470 | SDPRPHDKGIKRTAE | acetylation | [1] |
|
Reference | [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y. Mol Cell. 2013 Jun 27;50(6):919-30. [ PMID: 23806337] |
Functional Description | Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and NF-Y. RFX binds the X1 box of MHC-II promoters. |
Sequence Annotation | DNA_BIND 91 167 RFX-type winged-helix.
REGION 24 89 N-terminal domain (By similarity).
REGION 61 65 Leucine-rich region; critical for dimer
MOD_RES 184 184 Phosphoserine (By similarity). |
Keyword | Activator; Complete proteome; DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 658 AA |
Protein Sequence | MAEDKPDAKS PKTGARPQGG ADAGEPTTLL QRLRGTISKA VQNKVEGILQ EVQKFSDNDK 60
LYLYLQLPSG PSVGEKSSEP SLLSNEEYMY AYRWIRNHLE EHMDTCLPKQ SVYDAYRKYC 120
ESLACCRPLS TANFGKIIRE IFPDIKARRL GGRGQSKYCY SGIRRKTLVS MPPLPGLDLK 180
GSESPEMGPE VSPAPRDELV EAACALTCDW AERILKRSFS SIVQVARYLL QQHLISARSA 240
HAHVLKAGGL AEEDERAPRE RSLCKSKNVV ESLEGGGPKK PERPAQPPKE QEARAGTDLP 300
GRAERKKSVI DSSVPAASKP QVNALVARLP VLLPRAPRSL ITPISGTLKV ATLPLPTRVG 360
GPQTAVPIIN MILPPVPTLS GAGPGPGPGL GPRFGPGPGL GPGPGPGLGA GLGPGLGPGL 420
GAGPGPGLGA GLGAGLGLGP GRVPPRAPIL PRGAENREVG ISSDPRPHDK GIKRTAEVPL 480
SEASGQDPPV KEMKHETQDT TVSEAKRKRG RPRKKPGGSG ERNATPEKSA AIVNSPRSPR 540
LLWETWGSKR ENNFIGRPEG PGPGGEAERE TVLVQGQQDG AVSKGERSLS SQEAKEAEDK 600
IPPVTSKVSV IKGRIQKEAL QLVKGEADAA TQGNKGLKGR VLQSSLTPEH KDPKATPP 658 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0003677; F:DNA binding; IEA:UniProtKB-KW. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:MGI. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |