UniProt Accession

 MALD2_HUMAN; Q8N4S9; A1BQX0; A1BQX1; A8KA97; Q96NM9 

Genbank Protein ID

 AB219936; AB219937; DQ682656; DQ682657; AK055094; AK292962; AC145146; CH471137; BC033689 

Genbank Nucleotide ID

 BAE54513.1; BAE54514.1; ABG89104.1; ABG89105.1; BAB70853.1; BAF85651.1; EAW51277.1; AAH33689.1 

Protein Name

 MARVEL domain-containing protein 2 

Protein Synonyms/Alias

 Tricellulin 

Gene Name

 MARVELD2 

Gene Synonyms/Alias

 TRIC 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
87	RFVPDSWKNFFRGKK	ubiquitination	[1, 2]
134	RSPLNSCKDPYGGSE	ubiquitination	[3]
148	EGTFSSRKEADAVFP	ubiquitination	[3]
175	TVRTYSEKVEEYNLR	ubiquitination	[1, 2, 3]
391	NEPSLSSKRKMCEMA	ubiquitination	[3]
412	RDSEVNFKELRTAKM	ubiquitination	[3]
548	QRIQEYDKVMNWDVQ	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

 Plays a role in the formation of the epithelial barriers. The separation of the endolymphatic and perilymphatic spaces of the organ of Corti from one another by epithelial barriers is required for normal hearing. 

Sequence Annotation

 DOMAIN 188 367 MARVEL.
 MOD_RES 116 116 Phosphoserine.
 MOD_RES 120 120 Phosphoserine.  

Keyword

 Alternative splicing; Cell junction; Cell membrane; Coiled coil; Complete proteome; Deafness; Hearing; Membrane; Non-syndromic deafness; Phosphoprotein; Polymorphism; Reference proteome; Tight junction; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 558 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0033010; C:paranodal junction; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
 GO:0043220; C:Schmidt-Lanterman incisure; IEA:Compara.
 GO:0005923; C:tight junction; IDA:MGI.
 GO:0045216; P:cell-cell junction organization; IMP:MGI.
 GO:0007605; P:sensory perception of sound; IMP:MGI. 

Interpro

 IPR008253; Marvel.
 IPR021128; MARVEL-like_dom.
 IPR010844; Occludin_RNApol2_elong_fac_ELL. 

Pfam

 PF01284; MARVEL
 PF07303; Occludin_ELL 

SMART

  

PROSITE

 PS51225; MARVEL 

PRINTS