UniProt Accession

 HDGR2_MOUSE; Q3UMU9; D6CHX5; O35540; Q3UIH6; Q99L92 

Genbank Protein ID

 D63850; FN687734; AK143616; AK144669; AK146813; AK146918; BC003741 

Genbank Nucleotide ID

 BAA22896.1; CBK52221.2; BAE25467.1; BAE25999.1; BAE27453.1; BAE27530.1; AAH03741.1 

Protein Name

 Hepatoma-derived growth factor-related protein 2 

Protein Synonyms/Alias

 HRP-2 

Gene Name

 Hdgfrp2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
492	SEIKFALKVDNPDVR	ubiquitination	[1]
529	TDVVATLKKIRRYKA	ubiquitination	[1]
559	KSRVLGPKVEALQKV	ubiquitination	[1]
565	PKVEALQKVNKAGAE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Associates with chromatin. Isoform 1 and isoform 3 bind to condensed chromatin in mitotic cells. Isoform 4 binds to non- condensed chromatin in the presence of HDGF. 

Sequence Annotation

 DOMAIN 7 64 PWWP.
 MOD_RES 137 137 Phosphoserine (By similarity).
 MOD_RES 229 229 Phosphoserine (By similarity).
 MOD_RES 231 231 Phosphoserine.
 MOD_RES 233 233 Phosphoserine.
 MOD_RES 235 235 Phosphoserine.
 MOD_RES 239 239 Phosphoserine (By similarity).
 MOD_RES 366 366 Phosphoserine.
 MOD_RES 367 367 Phosphoserine.
 MOD_RES 389 389 Phosphothreonine.
 MOD_RES 391 391 Phosphoserine.
 MOD_RES 392 392 Phosphoserine.
 MOD_RES 393 393 Phosphoserine.
 MOD_RES 395 395 Phosphoserine.
 MOD_RES 450 450 Phosphoserine.
 MOD_RES 620 620 Phosphoserine.
 MOD_RES 628 628 Phosphoserine.
 MOD_RES 629 629 Phosphoserine (By similarity).
 MOD_RES 635 635 Phosphoserine.
 MOD_RES 640 640 Phosphoserine.
 MOD_RES 659 659 Phosphoserine.
 MOD_RES 661 661 Phosphoserine.  

Keyword

 Alternative splicing; Coiled coil; Complete proteome; Nucleus; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 669 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0006351; P:transcription, DNA-dependent; IEA:InterPro. 

Interpro

 IPR021567; LEDGF.
 IPR000313; PWWP.
 IPR017923; TFIIS_N. 

Pfam

 PF11467; LEDGF
 PF00855; PWWP 

SMART

 SM00293; PWWP 

PROSITE

 PS50812; PWWP 

PRINTS