| Tag | Content |
|---|
| CPLM ID | CPLM-024183 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Atrial natriuretic peptide-converting enzyme |
Protein Synonyms/Alias | Corin; Low density lipoprotein receptor-related protein 4; Pro-ANP-converting enzyme; Atrial natriuretic peptide-converting enzyme, N-terminal propeptide; Atrial natriuretic peptide-converting enzyme, activated protease fragment; Atrial natriuretic peptide-converting enzyme, 180 kDa soluble fragment |
Gene Name | Corin |
Gene Synonyms/Alias | Crn; Lrp4 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 71 | RGFLSGSKFQAPGSW | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Serine-type endopeptidase involved in atrial natriuretic peptide hormone (NPPA) processing. Converts through proteolytic cleavage the non-functional propeptide NPPA into the active hormone, thereby regulating blood pressure in heart and promoting natriuresis, diuresis and vasodilation. Proteolytic cleavage of pro-NPPA also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Also acts as a regulator of sodium reabsorption in kidney. May also process pro-NPPB the B-type natriuretic peptide. |
Sequence Annotation | DOMAIN 201 327 FZ 1.
DOMAIN 336 372 LDL-receptor class A 1.
DOMAIN 373 408 LDL-receptor class A 2.
DOMAIN 409 445 LDL-receptor class A 3.
DOMAIN 446 483 LDL-receptor class A 4.
DOMAIN 518 641 FZ 2.
DOMAIN 647 682 LDL-receptor class A 5.
DOMAIN 683 721 LDL-receptor class A 6.
DOMAIN 722 757 LDL-receptor class A 7.
DOMAIN 758 853 SRCR.
DOMAIN 869 1102 Peptidase S1.
ACT_SITE 910 910 Charge relay system (By similarity).
ACT_SITE 959 959 Charge relay system (By similarity).
ACT_SITE 1052 1052 Charge relay system (By similarity).
CARBOHYD 147 147 N-linked (GlcNAc...) (Potential).
CARBOHYD 202 202 N-linked (GlcNAc...) (Potential).
CARBOHYD 208 208 N-linked (GlcNAc...) (Potential).
CARBOHYD 298 298 N-linked (GlcNAc...) (Potential).
CARBOHYD 317 317 N-linked (GlcNAc...) (Potential).
CARBOHYD 373 373 N-linked (GlcNAc...) (Potential).
CARBOHYD 411 411 N-linked (GlcNAc...) (Potential).
CARBOHYD 444 444 N-linked (GlcNAc...) (Potential).
CARBOHYD 481 481 N-linked (GlcNAc...) (Potential).
CARBOHYD 519 519 N-linked (GlcNAc...) (Potential).
CARBOHYD 537 537 N-linked (GlcNAc...) (Potential).
CARBOHYD 635 635 N-linked (GlcNAc...) (Potential).
CARBOHYD 719 719 N-linked (GlcNAc...) (Potential).
CARBOHYD 765 765 N-linked (GlcNAc...) (Potential).
CARBOHYD 828 828 N-linked (GlcNAc...) (Potential).
CARBOHYD 970 970 N-linked (GlcNAc...) (Potential).
CARBOHYD 1089 1089 N-linked (GlcNAc...) (Potential).
DISULFID 206 266 By similarity.
DISULFID 214 259 By similarity.
DISULFID 250 290 By similarity.
DISULFID 279 324 By similarity.
DISULFID 283 307 By similarity.
DISULFID 337 350 By similarity.
DISULFID 345 363 By similarity.
DISULFID 357 372 By similarity.
DISULFID 374 386 By similarity.
DISULFID 381 399 By similarity.
DISULFID 393 408 By similarity.
DISULFID 410 423 By similarity.
DISULFID 418 436 By similarity.
DISULFID 430 445 By similarity.
DISULFID 447 460 By similarity.
DISULFID 455 473 By similarity.
DISULFID 467 482 By similarity.
DISULFID 523 586 By similarity.
DISULFID 531 579 By similarity.
DISULFID 570 608 By similarity.
DISULFID 597 638 By similarity.
DISULFID 601 625 By similarity.
DISULFID 648 660 By similarity.
DISULFID 655 673 By similarity.
DISULFID 667 682 By similarity.
DISULFID 684 698 By similarity.
DISULFID 692 711 By similarity.
DISULFID 705 720 By similarity.
DISULFID 723 735 By similarity.
DISULFID 730 748 By similarity.
DISULFID 742 757 By similarity.
DISULFID 782 884 By similarity.
DISULFID 857 979 Interchain (between N-terminal propeptide
DISULFID 895 911 By similarity.
DISULFID 993 1058 By similarity.
DISULFID 1022 1037 By similarity.
DISULFID 1048 1077 By similarity. |
Keyword | Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Membrane; Protease; Reference proteome; Repeat; Secreted; Serine protease; Signal-anchor; Transmembrane; Transmembrane helix; Zymogen. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1113 AA |
Protein Sequence | MGRVSFSVRV SSVRRARCSC PGRCYLSCRV PPTTALRALN GLGCAGVPGE TAGGAVGPGP 60
LGTRGFLSGS KFQAPGSWKD CFGAPPAPDV LRADRSVGEG CPQKLVTANL LRFLLLVLIP 120
CICALIVLLA ILLSFVGTLK RVYFKSNDSE PLVTDGEARV PGVIPVNTVY YENTGAPSLP 180
PSQSTPAWTP RAPSPEDQSH RNTSTCMNIT HSQCQILPYH STLAPLLPIV KNMDMEKFLK 240
FFTYLHRLSC YQHILLFGCS LAFPECVVDG DDRHGLLPCR SFCEAAKEGC ESVLGMVNSS 300
WPDSLRCSQF RDHTETNSSV RKSCFSLQQE HGKQSLCGGG ESFLCTSGLC VPKKLQCNGY 360
NDCDDWSDEA HCNCSKDLFH CGTGKCLHYS LLCDGYDDCG DLSDEQNCDC NLTKEHRCGD 420
GRCIAAEWVC DGDHDCVDKS DEVNCSCHSQ GLVECRSGQC IPSTFQCDGD EDCKDGSDEE 480
NCSDSQTPCP EGEQGCLGSS CVESCAGSSL CDSDSSLSNC SQCEPITLEL CMNLPYNHTH 540
YPNYLGHRTQ KEASISWESS LFPALVQTNC YKYLMFFACT ILVPKCDVNT GQRIPPCRLL 600
CEHSKERCES VLGIVGLQWP EDTDCNQFPE ESSDNQTCLL PNEDVEECSP SHFKCRSGRC 660
VLGSRRCDGQ ADCDDDSDEE NCGCKERALW ECPFNKQCLK HTLICDGFPD CPDSMDEKNC 720
SFCQDNELEC ANHECVPRDL WCDGWVDCSD SSDEWGCVTL SKNGNSSSLL TVHKSAKEHH 780
VCADGWRETL SQLACKQMGL GEPSVTKLIP GQEGQQWLRL YPNWENLNGS TLQELLVYRH 840
SCPSRSEISL LCSKQDCGRR PAARMNKRIL GGRTSRPGRW PWQCSLQSEP SGHICGCVLI 900
AKKWVLTVAH CFEGREDADV WKVVFGINNL DHPSGFMQTR FVKTILLHPR YSRAVVDYDI 960
SVVELSDDIN ETSYVRPVCL PSPEEYLEPD TYCYITGWGH MGNKMPFKLQ EGEVRIIPLE 1020
QCQSYFDMKT ITNRMICAGY ESGTVDSCMG DSGGPLVCER PGGQWTLFGL TSWGSVCFSK 1080
VLGPGVYSNV SYFVGWIERQ IYIQTFLQKK SQG 1113 |
Gene Ontology | GO:0009986; C:cell surface; IDA:MGI. GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell. GO:0005887; C:integral to plasma membrane; IEA:Compara. GO:0005044; F:scavenger receptor activity; IEA:InterPro. GO:0004252; F:serine-type endopeptidase activity; IMP:UniProtKB. GO:0070008; F:serine-type exopeptidase activity; IEA:InterPro. GO:0007565; P:female pregnancy; IMP:UniProtKB. GO:0030182; P:neuron differentiation; ISO:MGI. GO:0016486; P:peptide hormone processing; IMP:UniProtKB. GO:0006508; P:proteolysis; IEA:UniProtKB-KW. GO:0035813; P:regulation of renal sodium excretion; IMP:UniProtKB. GO:0003050; P:regulation of systemic arterial blood pressure by atrial natriuretic peptide; IMP:UniProtKB. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |