CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014269
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 ELAV-like protein 3 
Protein Synonyms/Alias
 Hu-antigen C; HuC 
Gene Name
 Elavl3 
Gene Synonyms/Alias
 Huc 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
69IGDIESCKLVRDKITubiquitination[1]
95SDPNDADKAINTLNGubiquitination[1]
104INTLNGLKLQTKTIKubiquitination[1]
134LYVSGLPKTMSQKEMubiquitination[1]
139LPKTMSQKEMEQLFSubiquitination[1]
209FANNPSQKTGQALLTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Binds to AU-rich sequences (AREs) of target mRNAs, including VEGF mRNA. May also bind poly-A tracts via RRM 3. May be involved in neuronal differentiation and maintenance. 
Sequence Annotation
 DOMAIN 39 117 RRM 1.
 DOMAIN 125 205 RRM 2.
 DOMAIN 284 362 RRM 3.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; Developmental protein; Differentiation; Neurogenesis; Reference proteome; Repeat; RNA-binding. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 367 AA 
Protein Sequence
MVTQILGAME SQVGGGPAGP ALPNGPLLGT NGATDDSKTN LIVNYLPQNM TQDEFKSLFG 60
SIGDIESCKL VRDKITGQSL GYGFVNYSDP NDADKAINTL NGLKLQTKTI KVSYARPSSA 120
SIRDANLYVS GLPKTMSQKE MEQLFSQYGR IITSRILLDQ ATGVSRGVGF IRFDKRIEAE 180
EAIKGLNGQK PLGAAEPITV KFANNPSQKT GQALLTHLYQ SSARRYAGPL HHQTQRFRLD 240
NLLNMAYGVK SPLSLIARFS PIAIDGMSGL AGVGLSGGAA GAGWCIFVYN LSPEADESVL 300
WQLFGPFGAV TNVKVIRDFT TNKCKGFGFV TMTNYDEAAM AIASLNGYRL GERVLQVSFK 360
TSKQHKA 367 
Gene Ontology
 GO:0017091; F:AU-rich element binding; IDA:UniProtKB.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007399; P:nervous system development; IEA:UniProtKB-KW. 
Interpro
 IPR006548; ELAD_HUD_SF.
 IPR002343; Hud_Sxl_RNA.
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS
 PR00961; HUDSXLRNA.