UniProt Accession

 NSRP1_HUMAN; Q9H0G5; Q6FI71 

Genbank Protein ID

 AL136806; CR533555; AC104984; BC040118; BC105044; BC105046 

Genbank Nucleotide ID

 CAB66740.1; CAG38586.1; AAH40118.1; AAI05045.1; AAI05047.1 

Protein Name

 Nuclear speckle splicing regulatory protein 1 

Protein Synonyms/Alias

 Coiled-coil domain-containing protein 55; Nuclear speckle-related protein 70; NSrp70 

Gene Name

 NSRP1 

Gene Synonyms/Alias

 CCDC55; NSRP70 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
25	QLHPVLQKPSVFGND	acetylation	[1]
499	SESSLGAKHRLTEEG	acetylation	[2, 3, 4]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.
 Kim SC, Sprung R, Chen Y, Xu Y, Ball H, Pei J, Cheng T, Kho Y, Xiao H, Xiao L, Grishin NV, White M, Yang XJ, Zhao Y.
 Mol Cell. 2006 Aug;23(4):607-18. [PMID: 16916647]
 [3] Proteome-wide prediction of acetylation substrates.
 Basu A, Rose KL, Zhang J, Beavis RC, Ueberheide B, Garcia BA, Chait B, Zhao Y, Hunt DF, Segal E, Allis CD, Hake SB.
 Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13785-90. [PMID: 19666589]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

 RNA-binding protein that mediates pre-mRNA alternative splicing regulation. 

Sequence Annotation

 REGION 106 170 Necessary for alternative splicing
 MOD_RES 27 27 Phosphoserine.
 MOD_RES 33 33 Phosphoserine.
 MOD_RES 248 248 Phosphoserine.
 MOD_RES 254 254 Phosphoserine.
 MOD_RES 255 255 Phosphoserine.
 MOD_RES 275 275 Phosphothreonine.  

Keyword

 Coiled coil; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; RNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 558 AA 

Protein Sequence

Gene Ontology

 GO:0016607; C:nuclear speck; IDA:UniProtKB.
 GO:0030529; C:ribonucleoprotein complex; IDA:UniProtKB.
 GO:0003729; F:mRNA binding; IDA:UniProtKB.
 GO:0032502; P:developmental process; IMP:UniProtKB.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0006913; P:nucleocytoplasmic transport; IDA:UniProtKB.
 GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IDA:UniProtKB.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR018612; DUF2040. 

Pfam

 PF09745; DUF2040 

SMART

  

PROSITE

  

PRINTS