CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019707
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Paired mesoderm homeobox protein 2B 
Protein Synonyms/Alias
 Neuroblastoma Phox; NBPhox; PHOX2B homeodomain protein; Paired-like homeobox 2B 
Gene Name
 PHOX2B 
Gene Synonyms/Alias
 PMX2B 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
84PYAAVPYKLFTDHGGubiquitination[1]
95DHGGLNEKRKQRRIRubiquitination[1]
111TFTSAQLKELERVFAubiquitination[1]
155NRRAKFRKQERAAAAubiquitination[1]
168AAAAAAAKNGSSGKKubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum- response element. 
Sequence Annotation
 DNA_BIND 98 157 Homeobox.  
Keyword
 Activator; Complete proteome; Developmental protein; Disease mutation; DNA-binding; Homeobox; Nucleus; Reference proteome; Transcription; Transcription regulation; Triplet repeat expansion. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 314 AA 
Protein Sequence
MYKMEYSYLN SSAYESCMAG MDTSSLASAY ADFSSCSQAS GFQYNPIRTT FGATSGCPSL 60
TPGSCSLGTL RDHQSSPYAA VPYKLFTDHG GLNEKRKQRR IRTTFTSAQL KELERVFAET 120
HYPDIYTREE LALKIDLTEA RVQVWFQNRR AKFRKQERAA AAAAAAAKNG SSGKKSDSSR 180
DDESKEAKST DPDSTGGPGP NPNPTPSCGA NGGGGGGPSP AGAPGAAGPG GPGGEPGKGG 240
AAAAAAAAAA AAAAAAAAAA GGLAAAGGPG QGWAPGPGPI TSIPDSLGGP FASVLSSLQR 300
PNGAKAALVK SSMF 314 
Gene Ontology
 GO:0000790; C:nuclear chromatin; IDA:BHF-UCL.
 GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:BHF-UCL.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0003360; P:brainstem development; IEP:BHF-UCL.
 GO:0021533; P:cell differentiation in hindbrain; ISS:BHF-UCL.
 GO:0071773; P:cellular response to BMP stimulus; ISS:BHF-UCL.
 GO:0071542; P:dopaminergic neuron differentiation; ISS:BHF-UCL.
 GO:0048894; P:efferent axon development in a lateral line nerve; ISS:BHF-UCL.
 GO:0048484; P:enteric nervous system development; IEP:BHF-UCL.
 GO:0010001; P:glial cell differentiation; ISS:BHF-UCL.
 GO:0021934; P:hindbrain tangential cell migration; ISS:BHF-UCL.
 GO:0048839; P:inner ear development; ISS:BHF-UCL.
 GO:0021723; P:medullary reticular formation development; ISS:BHF-UCL.
 GO:0008285; P:negative regulation of cell proliferation; IEA:Compara.
 GO:0045665; P:negative regulation of neuron differentiation; IEA:Compara.
 GO:1901166; P:neural crest cell migration involved in autonomic nervous system development; ISS:BHF-UCL.
 GO:0001764; P:neuron migration; ISS:BHF-UCL.
 GO:0003357; P:noradrenergic neuron differentiation; ISS:BHF-UCL.
 GO:0048486; P:parasympathetic nervous system development; ISS:BHF-UCL.
 GO:0045666; P:positive regulation of neuron differentiation; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:BHF-UCL.
 GO:0002087; P:regulation of respiratory gaseous exchange by neurological system process; ISS:BHF-UCL.
 GO:0060541; P:respiratory system development; ISS:BHF-UCL.
 GO:0061452; P:retrotrapezoid nucleus neuron differentiation; ISS:BHF-UCL.
 GO:0048485; P:sympathetic nervous system development; ISS:BHF-UCL.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR017970; Homeobox_CS.
 IPR001356; Homeodomain.
 IPR009057; Homeodomain-like. 
Pfam
 PF00046; Homeobox 
SMART
 SM00389; HOX 
PROSITE
 PS00027; HOMEOBOX_1
 PS50071; HOMEOBOX_2 
PRINTS