UniProt Accession

 ETV4_HUMAN; P43268; A8K314; B7Z5J3; B7Z9J6; Q96AW9 

Genbank Protein ID

 U18018; AF095890; AF095887; AF095888; AF095889; AK290429; AK299019; AK315961; AC068675; BC016623; D12765 

Genbank Nucleotide ID

 AAA95991.1; AAD09186.1; AAD09186.1; AAD09186.1; AAD09186.1; BAF83118.1; BAH12929.1; BAH14332.1; AAH16623.1; BAA02234.1 

Protein Name

 ETS translocation variant 4 

Protein Synonyms/Alias

 Adenovirus E1A enhancer-binding protein; E1A-F; Polyomavirus enhancer activator 3 homolog; Protein PEA3 

Gene Name

 ETV4 

Gene Synonyms/Alias

 E1AF; PEA3 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
6	**MERRMKAGYLDQQ	acetylation	[1]
21	VPYTFSSKSPGNGSL	acetylation	[1]
38	ALIGPLGKLMDPGSL	acetylation	[1]
96	HSPTTRIKKEPQSPR	acetylation	[1]
96	HSPTTRIKKEPQSPR	sumoylation	[2, 3]
97	SPTTRIKKEPQSPRT	ubiquitination	[4]
113	PALSCSRKPPLPYHH	acetylation	[1]
139	PPRQIAIKSPAPGAL	acetylation	[1]
226	PYPQQSFKQEYHDPL	sumoylation	[2, 3]
260	PGAGVVIKQEQTDFA	acetylation	[1]
260	PGAGVVIKQEQTDFA	sumoylation	[2, 3]
301	AMGYGYEKPLRPFPD	acetylation	[1]
316	DVCVVPEKFEGDIKQ	acetylation	[1]
322	EKFEGDIKQEGVGAF	sumoylation	[2]
441	DNQRPALKAEFDRPV	acetylation	[1]

Reference

 [1] Dynamic modification of the ETS transcription factor PEA3 by sumoylation and p300-mediated acetylation.
 Guo B, Panagiotaki N, Warwood S, Sharrocks AD.
 Nucleic Acids Res. 2011 Aug;39(15):6403-13. [PMID: 21543453]
 [2] Repression of E1AF transcriptional activity by sumoylation and PIASy.
 Nishida T, Terashima M, Fukami K, Yamada Y.
 Biochem Biophys Res Commun. 2007 Aug 17;360(1):226-32. [PMID: 17585876]
 [3] Extracellular signal-regulated kinase mitogen-activated protein kinase signaling initiates a dynamic interplay between sumoylation and ubiquitination to regulate the activity of the transcriptional activator PEA3.
 Guo B, Sharrocks AD.
 Mol Cell Biol. 2009 Jun;29(11):3204-18. [PMID: 19307308]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 

Functional Description

 Transcriptional activator that binds to the enhancer of the adenovirus E1A gene; the core-binding sequence is 5'[AC]GGA[AT]GT-3'. 

Sequence Annotation

 DNA_BIND 341 421 ETS.
 CROSSLNK 96 96 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 226 226 Glycyl lysine isopeptide (Lys-Gly)
 CROSSLNK 260 260 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Activator; Alternative splicing; Complete proteome; DNA-binding; Isopeptide bond; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Transcription; Transcription regulation; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 484 AA 

Protein Sequence

Gene Ontology

 GO:0005730; C:nucleolus; IDA:HPA.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; IEA:InterPro.
 GO:0060444; P:branching involved in mammary gland duct morphogenesis; IEA:Compara.
 GO:0008045; P:motor neuron axon guidance; IEA:Compara.
 GO:0033600; P:negative regulation of mammary gland epithelial cell proliferation; IEA:Compara.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; NAS:UniProtKB.
 GO:0060762; P:regulation of branching involved in mammary gland duct morphogenesis; IEA:Compara.
 GO:0048863; P:stem cell differentiation; IEA:Compara.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR000418; Ets_dom.
 IPR006715; ETS_PEA3_N.
 IPR011991; WHTH_DNA-bd_dom. 

Pfam

 PF00178; Ets
 PF04621; ETS_PEA3_N 

SMART

 SM00413; ETS 

PROSITE

 PS00345; ETS_DOMAIN_1
 PS00346; ETS_DOMAIN_2
 PS50061; ETS_DOMAIN_3 

PRINTS

 PR00454; ETSDOMAIN.