| Tag | Content |
|---|
| CPLM ID | CPLM-020973 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | DDB1- and CUL4-associated factor 6 |
Protein Synonyms/Alias | IQ motif and WD repeat-containing protein 1; Nuclear receptor interaction protein; NRIP |
Gene Name | Dcaf6 |
Gene Synonyms/Alias | Iqwd1 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 291 | DDTARELKTPSAEER | ubiquitination | [1] | | 710 | FRRRKERKEMEELDT | ubiquitination | [1] | | 816 | ESRIFNRKLADEVIT | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Ligand-dependent coactivator of nuclear receptors. Enhance transcriptional activity of the nuclear receptors NR3C1 and AR. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity). |
Sequence Annotation | REPEAT 49 88 WD 1.
REPEAT 92 133 WD 2.
REPEAT 139 179 WD 3.
REPEAT 189 229 WD 4.
REPEAT 251 290 WD 5.
DOMAIN 692 721 IQ.
REPEAT 734 772 WD 6.
REPEAT 775 814 WD 7.
MOD_RES 336 336 Phosphoserine (By similarity).
MOD_RES 665 665 Phosphoserine (By similarity).
MOD_RES 670 670 Phosphothreonine (By similarity).
MOD_RES 673 673 Phosphoserine. |
Keyword | Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Ubl conjugation pathway; WD repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 876 AA |
Protein Sequence | MARSGSCPHL LWDVRKRSLG LEDPSRLRSR YLGRREFIQR LKLEATLNVH DGCVNTICWN 60
DTGEYILSGS DDTKLVISNP YSRKVLTTIR SGHRANIFSA KFLPCTDDKQ IVSCSGDGVI 120
FYTNIEQDAE TNRQCQFTCH YGTTYEIMTV PNDPYTFLSC GEDGTVRWFD TRIKTSCTKE 180
DCKDDILINC RRAATSVAIC PPVPYYLAVG CSDSSVRIYD RRMLGTRATG NYAGRGTTGM 240
VARFIPSHLS NKSCRVTSLC YSEDGQEILV SYSSDYIYLF DPKDDTAREL KTPSAEERRE 300
ELRQPPVKRL RLRGDWSDTG PRARPESERE RDGEQSPNVS LMQRMSDMLS RWFEEASEVA 360
QSNRGRGRPR PRGGTNQPDV STLPTVPSSP NLEVCETAMD VDMPAALLQP STSSTDPVQA 420
QAATAAIESP RSSSLLSCPD SEPRQSVEAS GHHAHHQSDN SNERLSPKPG TGEPVLSLHY 480
STEGTTTSTI KLNFTDEWSS TASSSRGNGS HCKSEGQEEC LVPPSSVQPP EGDSETRAPE 540
ELSEKGTLPE NLTQNQIDTA QLDNFPAEPL DSNSGEKNNP SQDSPCGLPE EGTLSETDRE 600
TCEQASTESA TRHASTKPEL PSQTEAIEQA STESATRHTS ANPELPSQTE AIAPLAHEDP 660
SARDSALQDT DDSDDDPVLI PGARYRTGPG DRRSAVARIQ EFFRRRKERK EMEELDTLNI 720
RRPLVKMVYK GHRNSRTMIK EANFWGANFV MSGSDCGHIF IWDRHTAEHL MLLEADNHVV 780
NCLQPHPFDP ILASSGIDYD IKIWSPLEES RIFNRKLADE VITRNELMLE ETRNTITVPA 840
SFMLRMLASL NHIRADRLEG DRSEGSGQEN ENEDEE 876 |
Gene Ontology | GO:0080008; C:Cul4-RING ubiquitin ligase complex; ISS:UniProtKB. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; IEA:Compara. GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IEA:Compara. GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |