Tag | Content |
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CPLM ID | CPLM-014046 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ragulator complex protein LAMTOR3 |
Protein Synonyms/Alias | Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3; Mitogen-activated protein kinase kinase 1-interacting protein 1 |
Gene Name | Lamtor3 |
Gene Synonyms/Alias | Map2k1ip1 |
Created Date | July 27, 2013 |
Organism | Rattus norvegicus (Rat) |
NCBI Taxa ID | 10116 |
Lysine Modification | Position | Peptide | Type | References |
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11 | DLKRFLYKKLPSVEG | acetylation | [1] |
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Reference | [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns. Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV. Cell Rep. 2012 Aug 30;2(2):419-31. [ PMID: 22902405] |
Functional Description | As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2 (By similarity). |
Sequence Annotation | REGION 57 70 Required for interaction with LAMTOR2 (By |
Keyword | Complete proteome; Endosome; Membrane; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 124 AA |
Protein Sequence | MADDLKRFLY KKLPSVEGLH AIVVSDRDGV PVIKVANDSA PEHALRPGFL STFALATDQG 60 SKLGLSKNKS IICYYNTYQV VQFNRLPLVV SFIASSNANT GLIVSLEKEL APLFEELIKV 120 VEVS 124 |
Gene Ontology | GO:0071986; C:Ragulator complex; ISS:UniProtKB. GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:Compara. GO:0034613; P:cellular protein localization; ISS:UniProtKB. GO:0071230; P:cellular response to amino acid stimulus; ISS:UniProtKB. GO:0032008; P:positive regulation of TOR signaling cascade; ISS:UniProtKB. |
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