UniProt Accession

 HEBP1_MOUSE; Q9R257; O88814 

Genbank Protein ID

 AB013095; AF117613; CT010262; AC131718; BC012654 

Genbank Nucleotide ID

 BAA33770.1; AAD32096.1; CAJ18470.1; AAH12654.1 

Protein Name

 Heme-binding protein 1 

Protein Synonyms/Alias

 p22HBP 

Gene Name

 Hebp1 

Gene Synonyms/Alias

 Hbp 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
40	ERACEGGKFATVEVT	acetylation	[1]
40	ERACEGGKFATVEVT	ubiquitination	[2]
49	ATVEVTDKPVDEALR	ubiquitination	[2]
64	EAMPKIMKYVGGTND	ubiquitination	[2]
96	NEDGSLQKKLKVWFR	ubiquitination	[2]
121	APSDESVKIEEREGI	ubiquitination	[2]

Reference

 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May bind free porphyrinogens that may be present in the cell and thus facilitate removal of these potentially toxic compound. Binds with a high affinity to one molecule of heme or porphyrins. It binds metalloporphyrins, free porphyrins and N- methylprotoporphyrin with similar affinities. 

Sequence Annotation

  

Keyword

 3D-structure; Complete proteome; Cytoplasm; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 190 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:MGI.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0020037; F:heme binding; IDA:UniProtKB.
 GO:0042168; P:heme metabolic process; IC:MGI. 

Interpro

 IPR011256; Reg_factor_effector_bac.
 IPR006917; SOUL_haem-bd. 

Pfam

 PF04832; SOUL 

SMART

  

PROSITE

  

PRINTS