CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-021051
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Neurobeachin 
Protein Synonyms/Alias
 Lysosomal-trafficking regulator 2 
Gene Name
 Nbea 
Gene Synonyms/Alias
 Lyst2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
843KVVATLLKNSTPSAEubiquitination[1]
950AHKEYLAKMYEEYQRubiquitination[1]
1729ISSISQTKGINVKEIubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. May have a role in membrane trafficking. 
Sequence Annotation
 REPEAT 1316 1358 WD 1.
 DOMAIN 2264 2553 BEACH.
 REPEAT 2708 2751 WD 2.
 REPEAT 2768 2808 WD 3.
 REPEAT 2850 2889 WD 4.
 REPEAT 2892 2931 WD 5.
 MOD_RES 1519 1519 Phosphoserine.  
Keyword
 Alternative splicing; Cell junction; Cell membrane; Complete proteome; Membrane; Phosphoprotein; Postsynaptic cell membrane; Reference proteome; Repeat; Synapse; WD repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 2936 AA 
Protein Sequence
MASDKPGPGL EPQPVALLAV GAGGGAGGGG AMGEPRGAAG SGPVVLPAGM INPSVPIRNI 60
RMKFAVLIGL IQVGEVSNRD IVETVLNLLV GGEFDLEMNF IIQDAESITC MTELLEHCDV 120
TCQAEIWSMF TAILRKSVRN LQTSTEVGLI EQVLLKMSAV DDMIADLLVD MLGVLASYSI 180
TVKELKLLFS MLRGESGIWP RHAVKLLSVL NQMPQRHGPD TFFNFPGCSA AAIALPPIAK 240
WPYQNGFTLN TWFRMDPLNN INVDKDKPYL YCFRTSKGVG YSAHFVGNCL IVTSLKSKGK 300
GFQHCVKYDF QPRKWYMISI VHIYNRWRNS EIRCYVNGQL VSYGDMAWHV NTNDSYDKCF 360
LGSSETADAN RVFCGQLGAV YVFSEALNPA QIFAVHQLGP GYKSTFKFKS ESDIHLAEHH 420
KQVLYDGKLA SSIAFSYNAK ATDAQLCLES SPKENASIFV HSPHALMLQD VKAIVTHSIH 480
SAIHSIGGIQ VLFPLFAQLD NRQLNDSQVE TTVCATLLAF LVELLKSSVA MQEQMLGGKG 540
FLVIGYLLEK SSRVHITRAV LEQFLSFAKY LDGLSHGAPL LKQLCDHILF NPAIWIHTPA 600
KVQLSLYTYL SAEFIGTATI YTTIRRVGTV LQLMHTLKYY YWVINPADSS GIAPKGLDGP 660
RPSQKEIISL RAFMLLFLKQ LILKDRGVKE DELQSILNYL LTMHEDENIH DVLQLLVALM 720
SEHPASMIPA FDQRNGIRVI YKLLASKSES IWVQALKVLG YFLKHLGHKR KVEIMHTHSL 780
FTLLGERLML HTNTVTVTTY NTLYEILTEQ VCTQVVHKPH PEPDSTVKIQ NPMILKVVAT 840
LLKNSTPSAE LMEVRRLFLS DMIKLFSNSR ENRRCLLQCS VWQDWMFSLG YINPKSSEEQ 900
KITEMVYNIF RILLYHAIKY EWGGWRVWVD TLSIAHSKVT YEAHKEYLAK MYEEYQRQEE 960
ENIKKGKKGN VSTISGLSSQ TAGAKGGMEI REIEDLSQSQ SPESETDYPV STDTRDLLMS 1020
TKVSDDILGS SDRPGSGVHV EVHDLLVDIK AEKVEATEVK LDDMDLSPET LVGGENGALV 1080
EVESLLDNVY SAAVEKLQNN VHGSVGIIKK NEEKDNGPLI TLADEKEELP NSSTPFLFDK 1140
IPRQEEKLLP ELSSNHIIPN IQDTQVHLGV SDDLGLLAHM TASVELTCTS SIMEEKDFRI 1200
HTTSDGVSSV SERELASSTK GLDYAEMTAT TLETESSNSK AVPNVDAGSI ISDTERSDDG 1260
KESGKEIRKI QTTATTQAVQ GRSSTQQDRD LRVDLGFRGM PMTEEQRRQF SPGPRTTMFR 1320
IPEFKWSPMH QRLLTDLLFA LETDVHVWRS HSTKSVMDFV NSNENIIFVH NTIHLISQMV 1380
DNIIIACGGI LPLLSAATSP TGSKTELENI EVTQGMSAET AVTFLSRLMA MVDVLVFASS 1440
LNFSEIEAEK NMSSGGLMRQ CLRLVCCVAV RNCLECRQRQ RDRGSKSSHG SSKPQEAPHS 1500
VTAASASKTP LENVPGNLSP IKDPDRLLQD VDINRLRAVV FRDVDDSKQA QFLALAVVYF 1560
ISVLMVSKYR DILEPQRETA RTGSQPGRNI RQEINSPTST VVVIPSIPHP SLNHGLLAKL 1620
MPEQSFAHSF YKETPATFPD TVKEKETPTP GEDIQLESSV PHTDSGMGEE QVASILDGAE 1680
LEPAAGPDAM SELLSTLSSE VKKSQESLTE HPSEMLKPAP SISSISQTKG INVKEILKSL 1740
VAAPVEIAEC GPEPIPYPDP ALKREAHAIL PMQFHSFDRS VVVPVKKPPP GSLAVTTVGA 1800
TAAGSGLPTG STSSIFAAPG ATPKSMINTT GAVDSGSSSS SSSSSFVNGA TSKNLPAVQT 1860
VAPMPEDSAE NMSITAKLER ALEKVAPLLR EIFVDFAPFL SRTLLGSHGQ ELLIEGLVCM 1920
KSSTSVVELV MLLCSQEWQN SIQKNAGLAF IELINEGRLL CHAMKDHIVR VANEAEFILN 1980
RQRAEDVHKH AEFESQCAQY AADRREEEKM CDHLISAAKH RDHVTANQLK QKILNILTNK 2040
HGAWGAVSHS QLHDFWRLDY WEDDLRRRRR FVRNAFGSTH AEALLKSAVE YGTEEDVVKS 2100
KKAFRSQAIV NQNSETELML EGDDDAVSLL QEKEIDNLAG PVVLSTPAQL IAPVVVAKGT 2160
LSITTTEIYF EVDEDDAAFK KIDTKVLAYT EGLHGKWMFS EIRAVFSRRY LLQNTALEVF 2220
MANRTSVMFN FPDQATVKKV VYSLPRVGVG TSYGLPQARR ISLATPRQLY KSSNMTQRWQ 2280
RREISNFEYL MFLNTIAGRT YNDLNQYPVF PWVLTNYESE ELDLTLPGNF RDLSKPIGAL 2340
NPKRAVFYAE RYETWEEDQS PPFHYNTHYS TATSALSWLV RIEPFTTFFL NANDGKFDHP 2400
DRTFSSIARS WRTSQRDTSD VKELIPEFYY LPEMFVNSNG YHLGVREDEV VVNDVDLPPW 2460
AKKPEDFVRI NRMALESEFV SCQLHQWIDL IFGYKQRGPE AVRALNVFHY LTYEGSVNLD 2520
SITDPVLREA MEAQIQNFGQ TPSQLLIEPH PPRSSAMHLC FLPQSPLMFK DQMQQDVIMV 2580
LKFPSNSPVT HVAANTLPHL TIPAVVTVTC SRLFAVNRWH NTVGLRGAPG YSLDQAHHLP 2640
IEMDPLIANN SGVNKRQITD LVDQSIQINA HCFVVTADNR YILICGFWDK SFRVYSTETG 2700
KLTQIVFGHW DVVTCLARSE SYIGGDCYIV SGSRDATLLL WYWSGRHHII GDNPNSSDYP 2760
APRAVLTGHD HEVVCVSVCA ELGLVISGAK EGPCLVHTIT GDLLRALEGP ENCLFPRLIS 2820
VSSEGHCIIY YERGRFSNFS INGKLLAQME INDSTRAILL SSDGQNLVTG GDNGVVEVWQ 2880
ACDFKQLYIY PGCDAGIRAM DLSHDQRTLI TGMASGSIVA FNIDFNRWHY EHQNRY 2936 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0012505; C:endomembrane system; IDA:UniProtKB.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0045211; C:postsynaptic membrane; NAS:UniProtKB.
 GO:0005802; C:trans-Golgi network; IDA:UniProtKB.
 GO:0051018; F:protein kinase A binding; NAS:UniProtKB.
 GO:0019901; F:protein kinase binding; IDA:MGI.
 GO:0006892; P:post-Golgi vesicle-mediated transport; NAS:UniProtKB.
 GO:0006605; P:protein targeting; ISS:MGI. 
Interpro
 IPR016024; ARM-type_fold.
 IPR000409; BEACH_dom.
 IPR008985; ConA-like_lec_gl_sf.
 IPR013320; ConA-like_subgrp.
 IPR010508; DUF1088.
 IPR023362; PH-BEACH_dom.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR017986; WD40_repeat_dom. 
Pfam
 PF02138; Beach
 PF06469; DUF1088
 PF00400; WD40 
SMART
 SM01026; Beach
 SM00320; WD40 
PROSITE
 PS50197; BEACH
 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 
PRINTS