CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-031337
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Activin receptor type-2A 
Protein Synonyms/Alias
 cDNA FLJ51356, highly similar to Activin receptor type 2A (EC 2.7.11.30) 
Gene Name
 ACVR2A 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
118KIFPIQDKQSWQNEYubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Receptor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 405 AA 
Protein Sequence
MCNEKFSYFP EMEVTQPTSN PVTPKPPYYN ILLYSLVPLM LIAGIVICAF WVYRHHKMAY 60
PPVLVPTQDP GPPPPSPLLG LKPLQLLEVK ARGRFGCVWK AQLLNEYVAV KIFPIQDKQS 120
WQNEYEVYSL PGMKHENILQ FIGAEKRGTS VDVDLWLITA FHEKGSLSDF LKANVVSWNE 180
LCHIAETMAR GLAYLHEDIP GLKDGHKPAI SHRDIKSKNV LLKNNLTACI ADFGLALKFE 240
AGKSAGDTHG QVGTRRYMAP EVLEGAINFQ RDAFLRIDMY AMGLVLWELA SRCTAADGPV 300
DEYMLPFEEE IGQHPSLEDM QEVVVHKKKR PVLRDYWQKH AGMAMLCETI EECWDHDAEA 360
RLSAGCVGER ITQMQRLTNI ITTEDIVTVV TMVTNVDFPP KESSL 405 
Gene Ontology
 GO:0009986; C:cell surface; IEA:Compara.
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0017002; F:activin-activated receptor activity; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:InterPro.
 GO:0004702; F:receptor signaling protein serine/threonine kinase activity; IEA:InterPro.
 GO:0009952; P:anterior/posterior pattern specification; IEA:Compara.
 GO:0030509; P:BMP signaling pathway; IEA:Compara.
 GO:0007368; P:determination of left/right symmetry; IEA:Compara.
 GO:0048706; P:embryonic skeletal system development; IEA:Compara.
 GO:0001702; P:gastrulation with mouth forming second; IEA:Compara.
 GO:0007498; P:mesoderm development; IEA:Compara.
 GO:0043084; P:penile erection; IEA:Compara.
 GO:0030510; P:regulation of BMP signaling pathway; IEA:Compara.
 GO:0050999; P:regulation of nitric-oxide synthase activity; IEA:Compara.
 GO:0060011; P:Sertoli cell proliferation; IEA:Compara.
 GO:0023014; P:signal transduction by phosphorylation; IEA:GOC.
 GO:0042713; P:sperm ejaculation; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara. 
Interpro
 IPR000333; Activin_II/TGFBeta-II_recpt.
 IPR015768; Activin_II_recpt.
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
  
PROSITE
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS
 PR00653; ACTIVIN2R.