CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040296
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Ankyrin repeat and KH domain-containing protein 1 
Protein Synonyms/Alias
  
Gene Name
 ANKHD1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
45NSLSTSYKTVSLPLSubiquitination[1]
213STFQPANKLNKNVPTubiquitination[1, 2]
216QPANKLNKNVPTNVRubiquitination[1, 2, 3]
343RTPSSVRKQLFACVPubiquitination[1]
863HIGNMHLKYVN****ubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 866 AA 
Protein Sequence
MDVNSSKYPS LLLHSQEEKT STATSKTQTR LEGEVTPNSL STSYKTVSLP LSSPNIKLNL 60
TSPKRGQKRE EGWKEVVRRS KKLSVPASVV SRIMGRGGCN ITAIQDVTGA HIDVDKQKDK 120
NGERMITIRG GTESTRYAVQ LINALIQDPA KELEDLIPKN HIRTPASTKS IHANFSSGVG 180
TTAASSKNAF PLGAPTLVTS QATTLSTFQP ANKLNKNVPT NVRSSFPVSL PLAYPHPHFA 240
LLAAQTMQQI RHPRLPMAQF GGTFSPSPNT WGPFPVRPVN PGNTNSSPKH NNTSRLPNQN 300
GTVLPSESAG LATASCPITV SSVVAASQQL CVTNTRTPSS VRKQLFACVP KTSPPATVIS 360
SVTSTCSSLP SVSSAPITSG QAPTTFLPAS TSQAQLSSQK MESFSAVPPT KEKVSTQDQP 420
MANLCTPSST ANSCSSSASN TPGAPETHPS SSPTPTSSNT QEEAQPSSVS DLSPMSMPFA 480
SNSEPAPLTL TSPRMVAADN QDTSNLPQLA VPAPRVSHRM QPRGSFYSMV PNATIHQDPQ 540
SIFVTNPVTL TPPQGPPAAV QLSSAVNIMN GSQMHINPAN KSLPPTFGPA TLFNHFSSLF 600
DSSQVPANQG WGDGPLSSRV ATDASFTVQS AFLGNSVLGH LENMHPDNSK APGFRPPSQR 660
VSTSPVATSA PPTLGQPKGV SASQDRKIPP PIGTERLARI RQGGSVAQAP AGTSFVAPVG 720
HSGIWSFGVN AVSEGLSGWS QSVMGNHPMH QQLSDPSTFS QHQPMERDDS GMVAPSNIFH 780
QPMASGFVDF SKGLPISMYG GTIIPSHPQL ADVPGGPLFN GLHNPDPAWN PMIKVIQNST 840
ECTDAQQIWP GTWAPHIGNM HLKYVN 866 
Gene Ontology
 GO:0003723; F:RNA binding; IEA:InterPro. 
Interpro
 IPR004087; KH_dom.
 IPR004088; KH_dom_type_1. 
Pfam
 PF00013; KH_1 
SMART
 SM00322; KH 
PROSITE
 PS50084; KH_TYPE_1 
PRINTS