UniProt Accession

 TSNAX_MOUSE; Q9QZE7; Q3UJR2 

Genbank Protein ID

 AF187040; AK030407; AK146339; BC004611 

Genbank Nucleotide ID

 AAF05529.1; BAC26948.1; BAE27093.1; AAH04611.1 

Protein Name

 Translin-associated protein X 

Protein Synonyms/Alias

 Translin-associated factor X 

Gene Name

 Tsnax 

Gene Synonyms/Alias

 Trax 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
68	RDITVESKRTIFLLH	ubiquitination	[1]
93	ILTESESKLDGVRQK	ubiquitination	[1]
241	TGPYEVSKKLYTLKQ	acetylation	[2]
241	TGPYEVSKKLYTLKQ	ubiquitination	[1]
252	TLKQSLAKVENACYA	acetylation	[3]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis (By similarity). 

Sequence Annotation

 REGION 73 208 Interaction with C1D (By similarity).
 METAL 129 129 Magnesium (By similarity).
 METAL 197 197 Magnesium (By similarity).
 MOD_RES 237 237 Phosphotyrosine.  

Keyword

 Complete proteome; Cytoplasm; Developmental protein; Differentiation; DNA-binding; Golgi apparatus; Magnesium; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Spermatogenesis; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 290 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW. 

Interpro

 IPR002848; Translin.
 IPR016069; Translin_C.
 IPR016068; Translin_N. 

Pfam

 PF01997; Translin 

SMART

  

PROSITE

  

PRINTS