CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040018
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Cyclin-dependent kinase 17 
Protein Synonyms/Alias
  
Gene Name
 CDK17 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
90ISMEDLNKRLSLPADubiquitination[1]
107IPDGYLEKLQINSPPubiquitination[1, 2]
135LSEIGFGKMETYIKLubiquitination[1]
141GKMETYIKLEKLGEGubiquitination[2]
144ETYIKLEKLGEGTYAubiquitination[2]
155GTYATVYKGRSKLTEubiquitination[1]
262KVLHRDLKPQNLLINubiquitination[1]
271QNLLINEKGELKLADubiquitination[1]
275INEKGELKLADFGLAmethylation[3]
275INEKGELKLADFGLAubiquitination[2]
370ISSNEEFKNYNFPKYubiquitination[1]
378NYNFPKYKPQPLINHubiquitination[1]
399EGIELITKFLQYESKubiquitination[1]
406KFLQYESKKRVSAEEubiquitination[1]
416VSAEEAMKHVYFRSLubiquitination[1, 4]
440SVSIFSLKEIQLQKDubiquitination[1, 5]
446LKEIQLQKDPGFRNSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Large-scale global identification of protein lysine methylation in vivo.
 Cao XJ, Arnaudo AM, Garcia BA.
 Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]
 [4] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [5] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 470 AA 
Protein Sequence
MHSFLHQYTG SFKKPPLRRP HSVIGGSLGS FMAMPRNGSR LDIVHENLKM GSDGESDQAS 60
GTSSDEVQSP TGVCLRNRIH RRISMEDLNK RLSLPADIRI PDGYLEKLQI NSPPFDQPMS 120
RRSRRASLSE IGFGKMETYI KLEKLGEGTY ATVYKGRSKL TENLVALKEI RLEHEEGAPC 180
TAIREVSLLK DLKHANIVTL HDIVHTDKSL TLVFEYLDKD LKQYMDDCGN IMSMHNVKLF 240
LYQILRGLAY CHRRKVLHRD LKPQNLLINE KGELKLADFG LARAKSVPTK TYSNEVVTLW 300
YRPPDVLLGS SEYSTQIDMW GVGCIFFEMA SGRPLFPGST VEDELHLIFR LLGTPSQETW 360
PGISSNEEFK NYNFPKYKPQ PLINHAPRLD SEGIELITKF LQYESKKRVS AEEAMKHVYF 420
RSLGPRIHAL PESVSIFSLK EIQLQKDPGF RNSSYPETGV FVINHFTCRS 470 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004674; F:protein serine/threonine kinase activity; IEA:InterPro. 
Interpro
 IPR011009; Kinase-like_dom.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase 
SMART
 SM00220; S_TKc 
PROSITE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST 
PRINTS