CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010815
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Heterogeneous nuclear ribonucleoprotein U-like protein 2 
Protein Synonyms/Alias
 MLF1-associated nuclear protein 
Gene Name
 Hnrnpul2 
Gene Synonyms/Alias
 Hnrpul2; Manp 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
26GLDSRGLKMDLAQRLacetylation[1]
271GQPLFSEKFPTLWSGubiquitination[2]
303VTQNLPMKEGCTEVSacetylation[1]
469GKTQWALKYAKDNPEubiquitination[2]
551RRKLLLFKTFSRKVVubiquitination[2]
568VPNEEDWKRRLELRKubiquitination[2]
599ANFSLPEKCDYMDEVubiquitination[2]
622EAQPIVTKYKEEARKubiquitination[2]
636KLLPPSEKRTNRRNNubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
 DOMAIN 3 37 SAP.
 DOMAIN 224 417 B30.2/SPRY.
 MOD_RES 159 159 Phosphoserine.
 MOD_RES 186 186 Phosphoserine.
 MOD_RES 226 226 Phosphoserine (By similarity).  
Keyword
 Complete proteome; Nucleus; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 745 AA 
Protein Sequence
MEVKRLKVTE LRSELQRRGL DSRGLKMDLA QRLQEALDAE MLEDEAGVGG AGPGGACKAE 60
PRPVAASGGG PGGDEEEEDD DEEEDEEALL EDEDEEPPPA QALGQAAQPP PEPPETSAME 120
AESEASDTPA EATAGSGGVN GGEEHDNGKG EEDGPEERSG DETPGSEAPG DKAVEEQGDD 180
QDSEKSKPAG SDGERRGVKR QRDEKDEHGR AYYEFREEAY HSRSKSPPPP EEEAKDEEED 240
QTLVNLDTYT SDLHFQISKD RYGGQPLFSE KFPTLWSGAR STYGVTKGKV CFEAKVTQNL 300
PMKEGCTEVS LLRVGWSVDF SCSQLGEDEF SYGFDGRGLK AENGQFEEFG QTFGENDVIG 360
CFANFETEEV ELSFSKNGED LGVAFRISKE SLADRALLPH VLCKNCVVEL NFGQKEEPFF 420
PPPEEFVFIH AVPVEERVRT AVPPKTIEEC EVILMVGLPG SGKTQWALKY AKDNPERRYN 480
VLGAETVLTQ MRMKGLEEPE MDPKSRDLLV QQASQCLSKL VQIASRSKRN FILDQCNVYN 540
SGQRRKLLLF KTFSRKVVVV VPNEEDWKRR LELRKEVEGD DVPESIMLEM KANFSLPEKC 600
DYMDEVTYGE LEKEEAQPIV TKYKEEARKL LPPSEKRTNR RNNRNKRNRQ NRSRGQGYVG 660
GQRRGYDNRA YGQQYWGQSG NRGGYRNFYD RYRGDYERFY SRDYEYNRYR DYYRQYNRDW 720
QNYYYHHQQD RDRYYRNYYG YQGYR 745 
Gene Ontology
 GO:0005634; C:nucleus; IDA:UniProtKB.
 GO:0003676; F:nucleic acid binding; IEA:InterPro. 
Interpro
 IPR001870; B30.2/SPRY.
 IPR008985; ConA-like_lec_gl_sf.
 IPR027026; hnRNP_U_like_2.
 IPR027417; P-loop_NTPase.
 IPR003034; SAP_dom.
 IPR018355; SPla/RYanodine_receptor_subgr.
 IPR003877; SPRY_rcpt. 
Pfam
 PF02037; SAP
 PF00622; SPRY 
SMART
 SM00513; SAP
 SM00449; SPRY 
PROSITE
 PS50188; B302_SPRY
 PS50800; SAP 
PRINTS