UniProt Accession

 TTC33_HUMAN; Q6PID6; B2R6G0; O95105 

Genbank Protein ID

 AF023244; AK312560; CH471119; BC015701; BC036536 

Genbank Nucleotide ID

 AAD09341.1; BAG35457.1; EAW55998.1; AAH15701.1; AAH36536.1 

Protein Name

 Tetratricopeptide repeat protein 33 

Protein Synonyms/Alias

 TPR repeat protein 33; Osmosis-responsive factor 

Gene Name

 TTC33 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
13	WKRKIGEKVSKVTSQ	acetylation	[1]
16	KIGEKVSKVTSQQFE	ubiquitination	[2]
48	LHAIKRRKEILLEGC	ubiquitination	[3]
58	LLEGCAEKSKQLKDE	ubiquitination	[3]
179	RTLQEQQKVAQRIKK	ubiquitination	[2, 3]

Reference

 [1] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

  

Sequence Annotation

 REPEAT 59 92 TPR 1.
 REPEAT 93 126 TPR 2.
 REPEAT 127 160 TPR 3.
 MOD_RES 197 197 Phosphoserine.  

Keyword

 Complete proteome; Phosphoprotein; Polymorphism; Reference proteome; Repeat; TPR repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 262 AA 

Protein Sequence

Gene Ontology

  

Interpro

 IPR013026; TPR-contain_dom.
 IPR011990; TPR-like_helical.
 IPR019734; TPR_repeat. 

Pfam

  

SMART

  

PROSITE

 PS50005; TPR
 PS50293; TPR_REGION 

PRINTS