CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018633
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Biotin--protein ligase 
Protein Synonyms/Alias
 Biotin apo-protein ligase; Biotin--[methylmalonyl-CoA-carboxytransferase] ligase; Biotin--[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase; Holocarboxylase synthetase; HCS; Biotin--[methylcrotonoyl-CoA-carboxylase] ligase; Biotin--[acetyl-CoA-carboxylase] ligase 
Gene Name
 Hlcs 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
625KQHGAGLKPLRADCLacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
 Post-translational modification of specific protein by attachment of biotin. Acts on various carboxylases such as acetyl- CoA-carboxylase, pyruvate carboxylase, propionyl CoA carboxylase, and 3-methylcrotonyl CoA carboxylase (By similarity). 
Sequence Annotation
 MOD_RES 122 122 Phosphoserine.  
Keyword
 ATP-binding; Complete proteome; Cytoplasm; Ligase; Mitochondrion; Multifunctional enzyme; Nucleotide-binding; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 722 AA 
Protein Sequence
MEDRLQMDNG LIAQKIVSVH LKDPALKELG KASDKQVQGP PPGPEASPEA QPAQGVMEHA 60
GQGDCKAAGE GPSPRRRGCA PESEPAADGD PGLSSPELCQ LHLSICHECL ELENSTIDSV 120
RSASAENIPD LPCDHSGVEG AAGELCPERK GKRVNISGKA PNILLYVGSG SEEALGRLQQ 180
VRSVLTDCVD TDSYTLYHLL EDSALRDPWS DNCLLLVIAS RDPIPKDIQH KFMAYLSQGG 240
KVLGLSSPFT LGGFRVTRRD VLRNTVQNLV FSKADGTEVR LSVLSSGYVY EEGPSLGRLQ 300
GHLENEDKDK MIVHVPFGTL GGEAVLCQVH LELPPGASLV QTADDFNVLK SSNVRRHEVL 360
KEILTALGLS CDAPQVPALT PLYLLLAAEE TQDPFMQWLG RHTDPEGIIK SSKLSLQFVS 420
SYTSEAEITP SSMPVVTDPE AFSSEHFSLE TYRQNLQTTR LGKVILFAEV TSTTMSLLDG 480
LMFEMPQEMG LIAIAVRQTQ GKGRGPNAWL SPVGCALSTL LVFIPLRSQL GQRIPFVQHL 540
MSLAVVEAVR SIPGYEDINL RVKWPNDIYY SDLMKIGGVL VNSTLMGETF YILIGCGFNV 600
TNSNPTICIN DLIEEHNKQH GAGLKPLRAD CLIARAVTVL EKLIDRFQDQ GPDGVLPLYY 660
KYWVHGGQQV RLGSTEGPQA SIVGLDDSGF LQVHQEDGGV VTVHPDGNSF DMLRNLIVPK 720
RQ 722 
Gene Ontology
 GO:0000785; C:chromatin; ISS:BHF-UCL.
 GO:0005829; C:cytosol; ISS:BHF-UCL.
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005652; C:nuclear lamina; ISS:BHF-UCL.
 GO:0016363; C:nuclear matrix; ISS:BHF-UCL.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0009374; F:biotin binding; ISS:BHF-UCL.
 GO:0004077; F:biotin-[acetyl-CoA-carboxylase] ligase activity; IEA:EC.
 GO:0004078; F:biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity; IEA:EC.
 GO:0004079; F:biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity; IEA:EC.
 GO:0004080; F:biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity; ISS:BHF-UCL.
 GO:0019899; F:enzyme binding; ISS:BHF-UCL.
 GO:0042803; F:protein homodimerization activity; ISS:BHF-UCL.
 GO:0008283; P:cell proliferation; ISS:BHF-UCL.
 GO:0071110; P:histone biotinylation; ISS:BHF-UCL.
 GO:0070781; P:response to biotin; ISS:BHF-UCL. 
Interpro
 IPR004408; Biotin_CoA_COase_ligase.
 IPR003142; BPL_C.
 IPR004143; BPL_LipA_LipB. 
Pfam
 PF02237; BPL_C
 PF03099; BPL_LplA_LipB 
SMART
  
PROSITE
  
PRINTS