UniProt Accession

 CP7B1_HUMAN; O75881; B2RN07; Q9UNF5 

Genbank Protein ID

 AF029403; AF127090; AF176805; AF176800; AF176801; AF176802; AF176803; AF176804; CH471068; BC136574 

Genbank Nucleotide ID

 AAC95426.1; AAD20021.1; AAK11850.1; AAK11850.1; AAK11850.1; AAK11850.1; AAK11850.1; AAK11850.1; EAW86877.1; AAI36575.1 

Protein Name

 25-hydroxycholesterol 7-alpha-hydroxylase 

Protein Synonyms/Alias

 Cytochrome P450 7B1; Oxysterol 7-alpha-hydroxylase 

Gene Name

 CYP7B1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
218	ELRDDFLKFDDKFAY	ubiquitination	[1, 2]
256	FSSEKLAKMQGWSEV	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

  

Sequence Annotation

 METAL 449 449 Iron (heme axial ligand) (By similarity).  

Keyword

 Cholesterol metabolism; Complete proteome; Disease mutation; Endoplasmic reticulum; Heme; Hereditary spastic paraplegia; Intrahepatic cholestasis; Iron; Lipid metabolism; Membrane; Metal-binding; Microsome; Monooxygenase; NADP; Neurodegeneration; Oxidoreductase; Reference proteome; Steroid metabolism; Sterol metabolism. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 506 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; TAS:Reactome.
 GO:0033783; F:25-hydroxycholesterol 7alpha-hydroxylase activity; IEA:EC.
 GO:0009055; F:electron carrier activity; IEA:InterPro.
 GO:0020037; F:heme binding; IEA:InterPro.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0008396; F:oxysterol 7-alpha-hydroxylase activity; TAS:ProtInc.
 GO:0006699; P:bile acid biosynthetic process; TAS:Reactome.
 GO:0008219; P:cell death; IEA:UniProtKB-KW.
 GO:0008203; P:cholesterol metabolic process; IEA:UniProtKB-KW.
 GO:0033147; P:negative regulation of intracellular estrogen receptor signaling pathway; IEA:Compara.
 GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Compara.
 GO:0060740; P:prostate gland epithelium morphogenesis; IEA:Compara.
 GO:0006805; P:xenobiotic metabolic process; TAS:Reactome. 

Interpro

 IPR001128; Cyt_P450.
 IPR024204; Cyt_P450_CYP7A1-type.
 IPR002403; Cyt_P450_E_grp-IV. 

Pfam

 PF00067; p450 

SMART

  

PROSITE

 PS00086; CYTOCHROME_P450 

PRINTS

 PR00465; EP450IV.
 PR00385; P450.