CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042000
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 28S ribosomal protein S22, mitochondrial 
Protein Synonyms/Alias
 Mitochondrial ribosomal protein S22, isoform CRA_a 
Gene Name
 MRPS22 
Gene Synonyms/Alias
 hCG_17223 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
98KPAIQELKPPTYKLMubiquitination[1]
103ELKPPTYKLMTQAQLubiquitination[2]
126EAAKVRLKMPPVLEEubiquitination[1, 3, 4, 5]
145NDVLAEDKILEGTETubiquitination[1, 3]
154LEGTETTKYVFTDISubiquitination[1]
198MIQVYFPKEGRKILTubiquitination[1, 2, 3, 4]
210ILTPIIFKEENLRTMacetylation[6]
210ILTPIIFKEENLRTMubiquitination[1, 3]
254KTYEDIDKRGKYDLLacetylation[6]
254KTYEDIDKRGKYDLLubiquitination[4]
279WYFVNNKKIDGLLIDubiquitination[4]
328AEGINLIKVFAKTEAubiquitination[1, 2, 3, 4]
332NLIKVFAKTEAQKGAubiquitination[4]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [6] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome; Ribonucleoprotein; Ribosomal protein. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 359 AA 
Protein Sequence
MAPLGTTVLL WSLLRSSPGV ERVCFRARIQ PWHGGLLQPL PCSFEMGLPR RRFSSEAESG 60
SPETKKPTFM DEEVQSILTK MTGLNLQKTF KPAIQELKPP TYKLMTQAQL EEATRQAVEA 120
AKVRLKMPPV LEERVPINDV LAEDKILEGT ETTKYVFTDI SYSIPHRERF IVVREPSGTL 180
RKASWEERDR MIQVYFPKEG RKILTPIIFK EENLRTMYSQ DRHVDVLNLC FAQFEPDSTE 240
YIKVHHKTYE DIDKRGKYDL LRSTRYFGGM VWYFVNNKKI DGLLIDQIQR DLIDDATNLV 300
QLYHVLHPDG QSAQGAKDQA AEGINLIKVF AKTEAQKGAY IELTLQTYQE ALSRHSAAS 359 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0005840; C:ribosome; IEA:UniProtKB-KW. 
Interpro
 IPR019374; Ribosomal_S22_mit. 
Pfam
 PF10245; MRP-S22 
SMART
  
PROSITE
  
PRINTS