CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014125
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cysteine-rich hydrophobic domain 1 protein 
Protein Synonyms/Alias
 Brain X-linked protein 
Gene Name
 CHIC1 
Gene Synonyms/Alias
 BRX 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
176RTRRSIQKLIEWENNubiquitination[1, 2, 3, 4, 5, 6, 7]
Reference
 [1] Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level.
 Danielsen JM, Sylvestersen KB, Bekker-Jensen S, Szklarczyk D, Poulsen JW, Horn H, Jensen LJ, Mailand N, Nielsen ML.
 Mol Cell Proteomics. 2011 Mar;10(3):M110.003590. [PMID: 21139048]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [5] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [7] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789
Functional Description
  
Sequence Annotation
  
Keyword
 Alternative splicing; Cell membrane; Coiled coil; Complete proteome; Cytoplasmic vesicle; Lipoprotein; Membrane; Palmitate; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 224 AA 
Protein Sequence
MSILLPNMAE FDTISELEEE EEEEAATSSS SPSSSSSVSG PDDDEEDEEE EEEEEEEEEE 60
EEEEEEEEAP PPPRVVSEEH LRRYAPDPVL VRGAGHITVF GLSNKFDTEF PSVLTGKVAP 120
EEFKTSIGRV NACLKKALPV NVKWLLCGCL CCCCTLGCSL WPVICLNKRT RRSIQKLIEW 180
ENNRLYHKLA LHWKLTKRKC ETSNMMEYVI LIEFLPKYPI FRPD 224 
Gene Ontology
 GO:0016023; C:cytoplasmic membrane-bounded vesicle; IEA:UniProtKB-SubCell.
 GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell. 
Interpro
 IPR019383; Golgin_A_7/ERF4. 
Pfam
 PF10256; Erf4 
SMART
  
PROSITE
  
PRINTS