CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010335
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mhp operon transcriptional activator 
Protein Synonyms/Alias
  
Gene Name
 mhpR 
Gene Synonyms/Alias
 b0346; JW0337 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
184QLAREPLKLEAILARacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618
Functional Description
 Activator of the mhpRABCDEF operon coding for components of the 3-hydroxyphenylpropionate degradation pathway. 
Sequence Annotation
 DOMAIN 12 74 HTH iclR-type.
 DOMAIN 89 262 IclR-ED.
 DNA_BIND 34 53 H-T-H motif (Potential).  
Keyword
 Activator; Aromatic hydrocarbons catabolism; Complete proteome; DNA-binding; Reference proteome; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 277 AA 
Protein Sequence
MQNNEQTEYK TVRGLTRGLM LLNMLNKLDG GASVGLLAEL SGLHRTTVRR LLETLQEEGY 60
VRRSPSDDSF RLTIKVRQLS EGFRDEQWIS ALAAPLLGDL LREVVWPTDV STLDVDAMVV 120
RETTHRFSRL SFHRAMVGRR LPLLKTASGL TWLAFCPEQD RKELIEMLAS RPGDDYQLAR 180
EPLKLEAILA RARKEGYGQN YRGWDQEEKI ASIAVPLRSE QRVIGCLNLV YMASAMTIEQ 240
AAEKHLPALQ RVAKQIEEGV ESQAILVAGR RSGMHLR 277 
Gene Ontology
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR014757; Tscrpt_reg_IclR_C.
 IPR005471; Tscrpt_reg_IclR_N.
 IPR011991; WHTH_DNA-bd_dom. 
Pfam
 PF09339; HTH_IclR
 PF01614; IclR 
SMART
 SM00346; HTH_ICLR 
PROSITE
 PS51077; HTH_ICLR
 PS51078; ICLR_ED 
PRINTS