CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010831
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Collagen alpha-2(I) chain 
Protein Synonyms/Alias
 Alpha-2 type I collagen 
Gene Name
 Col1a2 
Gene Synonyms/Alias
 Cola2 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
1070GPSGPVGKDGRSGQPacetylation[1]
1070GPSGPVGKDGRSGQPsuccinylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
 Type I collagen is a member of group I collagen (fibrillar forming collagen). 
Sequence Annotation
 DOMAIN 1139 1372 Fibrillar collagen NC1.
 METAL 1187 1187 Calcium (By similarity).
 METAL 1189 1189 Calcium (By similarity).
 METAL 1190 1190 Calcium; via carbonyl oxygen (By
 METAL 1192 1192 Calcium; via carbonyl oxygen (By
 METAL 1195 1195 Calcium (By similarity).
 MOD_RES 86 86 Pyrrolidone carboxylic acid (By
 MOD_RES 90 90 Allysine (By similarity).
 CARBOHYD 1273 1273 N-linked (GlcNAc...) (Potential).
 DISULFID 1169 1201 By similarity.
 DISULFID 1209 1370 By similarity.
 DISULFID 1278 1323 By similarity.  
Keyword
 Calcium; Collagen; Complete proteome; Disulfide bond; Extracellular matrix; Glycoprotein; Hydroxylation; Metal-binding; Pyrrolidone carboxylic acid; Reference proteome; Repeat; Secreted; Signal. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1372 AA 
Protein Sequence
MLSFVDTRTL LLLAVTSCLA TCQYLQSGSV RKGPTGDRGP RGQRGPAGPR GRDGVDGPMG 60
PPGPPGSPGP PGSPAPPGLT GNFAAQYSDK GVSSGPGPMG LMGPRGPPGA VGAPGPQGFQ 120
GPAGEPGEPG QTGPAGPRGP AGSPGKAGED GHPGKPGRPG ERGVVGPQGA RGFPGTPGLP 180
GFKGVKGHSG MDGLKGQPGA QGVKGEPGAP GENGTPGQAG ARGLPGERGR VGAPGPAGAR 240
GSDGSVGPVG PAGPIGSAGP PGFPGAPGPK GELGPVGNPG PAGPAGPRGE VGLPGLSGPV 300
GPPGNPGTNG LTGAKGATGL PGVAGAPGLP GPRGIPGPAG AAGATGARGL VGEPGPAGSK 360
GESGNKGEPG SVGAQGPPGP SGEEGKRGSP GEAGSAGPAG PPGLRGSPGS RGLPGADGRA 420
GVMGPPGNRG STGPAGIRGP NGDAGRPGEP GLMGPRGLPG SPGNVGPSGK EGPVGLPGID 480
GRPGPIGPAG PRGEAGNIGF PGPKGPSGDP GKPGERGHPG LAGARGAPGP DGNNGAQGPP 540
GPQGVQGGKG EQGPAGPPGF QGLPGPSGTT GEVGKPGERG LPGEFGLPGP AGPRGERGTP 600
GESGAAGPSG PIGSRGPSGA PGPDGNKGEA GAVGAPGSAG ASGPGGLPGE RGAAGIPGGK 660
GEKGETGLRG DTGNTGRDGA RGIPGAVGAP GPAGASGDRG EAGAAGPSGP AGPRGSPGER 720
GEVGPAGPNG FAGPAGAAGQ PGAKGEKGTK GPKGENGIVG PTGSVGAAGP SGPNGPPGPV 780
GSRGDGGPPG MTGFPGAAGR TGPPGPSGIA GPPGPPGAAG KEGIRGPRGD QGPVGRTGET 840
GASGPPGFVG EKGPSGEPGT AGAPGTAGPQ GLLGAPGILG LPGSRGERGL PGIAGALGEP 900
GPLGISGPPG ARGPPGAVGS PGVNGAPGEA GRDGNPGSDG PPGRDGQPGH KGERGYPGSI 960
GPTGAAGAPG PHGSVGPAGK HGNRGEPGPA GSVGPVGAVG PRGPSGPQGI RGDKGEPGDK 1020
GHRGLPGLKG YSGLQGLPGL AGLHGDQGAP GPVGPAGPRG PAGPSGPVGK DGRSGQPGPV 1080
GPAGVRGSQG SQGPAGPPGP PGPPGPPGVS GGGYDFGFEG DFYRADQPRS QPSLRPKDYE 1140
VDATLKSLNN QIETLLTPEG SRKNPARTCR DLRLSHPEWN SDYYWIDPNQ GCTMDAIKVY 1200
CDFSTGETCI QAQPVNTPAK NSYSRAQANK HVWLGETING GSQFEYNVEG VSSKEMATQL 1260
AFMRLLANRA SQNITYHCKN SIAYLDEETG SLNKAVLLQG SNDVELVAEG NSRFTYSVLV 1320
DGCSKKTNEW GKTIIEYKTN KPSRLPFLDI APLDIGGADQ EFRVEVGPVC FK 1372 
Gene Ontology
 GO:0005584; C:collagen type I; IDA:MGI.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0005201; F:extracellular matrix structural constituent; IEA:InterPro.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0001568; P:blood vessel development; IEA:Compara.
 GO:0071230; P:cellular response to amino acid stimulus; IDA:MGI.
 GO:0030199; P:collagen fibril organization; IEA:Compara.
 GO:0070208; P:protein heterotrimerization; IDA:MGI.
 GO:0008217; P:regulation of blood pressure; IEA:Compara.
 GO:0007266; P:Rho protein signal transduction; IEA:Compara.
 GO:0001501; P:skeletal system development; IEA:Compara.
 GO:0043589; P:skin morphogenesis; IEA:Compara.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Compara. 
Interpro
 IPR008160; Collagen.
 IPR000885; Fib_collagen_C. 
Pfam
 PF01410; COLFI
 PF01391; Collagen 
SMART
 SM00038; COLFI 
PROSITE
 PS51461; NC1_FIB 
PRINTS