CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-037133
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Splicing factor 3A subunit 3 
Protein Synonyms/Alias
  
Gene Name
 SF3A3 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
95DLHDCYLKYINLKASubiquitination[1, 2]
100YLKYINLKASEKLDYubiquitination[2]
148QDYTDRVKPLQDQNEubiquitination[2, 3, 4]
159DQNELFGKIQAEFEKubiquitination[2]
166KIQAEFEKKWENGTFacetylation[5]
238RLFSTKGKSLESLDTubiquitination[2]
250LDTSLFAKNPKSKGTubiquitination[2]
253SLFAKNPKSKGTKRDubiquitination[2]
337LPLGWDGKPIPYWLYubiquitination[2, 3]
413WAKLKLQKASERWQPubiquitination[2]
436SSGNVVNKKTYEDLKubiquitination[1, 4]
443KKTYEDLKRQGLL**ubiquitination[2]
Reference
 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 448 AA 
Protein Sequence
METILEQQRR YHEEKERLMD VMAKEMLTKK STLRDQINSD HRTRAMQDIC VPMSVEFEEL 60
LKARENPSEE AQNLVEFTDE EGYGRYLDLH DCYLKYINLK ASEKLDYITY LSIFDQLFDI 120
PKERKNAEYK RYLEMLLEYL QDYTDRVKPL QDQNELFGKI QAEFEKKWEN GTFPGWPKET 180
SSALTHAGAH LDLSAFSSWE ELASLGLDRL KSALLALGLK CGGTLEERAQ RLFSTKGKSL 240
ESLDTSLFAK NPKSKGTKRD TERNKDIAFL EAQIYEYVEI LGEQRHLTHE NVQRKQARTG 300
EEREEEEEEQ ISESESEDEE NEIIYNPKNL PLGWDGKPIP YWLYKLHGLN INYNCEICGN 360
YTYRGPKAFQ RHFAEWRHAH GMRCLGIPNT AHFANVTQIE DAVSLWAKLK LQKASERWQP 420
DTEEEYEDSS GNVVNKKTYE DLKRQGLL 448 
Gene Ontology
 GO:0005634; C:nucleus; IEA:InterPro.
 GO:0003676; F:nucleic acid binding; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR024598; DUF3449.
 IPR015880; Znf_C2H2-like.
 IPR000690; Znf_C2H2_matrin. 
Pfam
 PF11931; DUF3449 
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS50171; ZF_MATRIN 
PRINTS