CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-011645
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RNA-binding protein MRN1 
Protein Synonyms/Alias
 Multicopy suppressor of RSC-NHP6 synthetic lethality protein 1; Post-transcriptional regulator of 69 kDa 
Gene Name
 MRN1 
Gene Synonyms/Alias
 PTR69; YPL184C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
111QPTQFQTKQRNDSQQubiquitination[1]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301] 
Functional Description
 RNA-binding protein that binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES). Probably involved in translational regulation. 
Sequence Annotation
 DOMAIN 201 274 RRM 1.
 DOMAIN 292 379 RRM 2.
 DOMAIN 431 504 RRM 3.
 DOMAIN 522 602 RRM 4.  
Keyword
 Complete proteome; Cytoplasm; Reference proteome; Repeat; RNA-binding; Translation regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 612 AA 
Protein Sequence
MVVSYNNNNN NNNNNNNNNI SNNNNNNNMF PPFPSSDDFA MYQQSSSSGP YQETYASGPQ 60
NFGDAVYPMN GNFTLLPSDF TREPNDSFFY ENDGIFDYQR IQQQPTQFQT KQRNDSQQQR 120
FSQEQNFEID NEVVHNNNRY YEYERSSNEV SPFDDENPNV LSDGMSPTIM ATATAVTNAN 180
APLPVNAQAN NPLNFTSAPS RTVYLGNVPP NLSVKELLDH VRSGVVEDVK IIPEKMCAFV 240
SFIDESAALL FHSDAILKRL NIGDRDIKIG WGKPTRIDPI VAARISTDGA TRNVYIGRMT 300
IEGEESHLSE EQLRVDLEEY GEIDCIKIIK EKGIAFIHFA SILNAIKVVT NLPIRNPYYQ 360
NKRIFYGKDR CAFITKTQQH NAAQFLGVQP GMEHMIEFSD REFISNALLQ QSAAAAAIAT 420
SAGGPNNLGN RTVYLGSLPK DVKIEEICNA VRGGLLQSIK LLNDRYVCFV TFIDPTAAAQ 480
FYAMSSLYGF TVQKKRCKVG WGKHSGPLPN ALALAVSNGA SRNVYVGNID FVGDSLRDER 540
VFTESNLRHI FQQYGEVEQI NFLPEKNCCF INYTNISNAI LALDKIKSNP YFKDLKINFG 600
KDRCGNVPHQ SR 612 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0000166; F:nucleotide binding; IEA:InterPro.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0006338; P:chromatin remodeling; IGI:SGD.
 GO:0000398; P:mRNA splicing, via spliceosome; IGI:SGD.
 GO:0006417; P:regulation of translation; IEA:UniProtKB-KW. 
Interpro
 IPR012677; Nucleotide-bd_a/b_plait.
 IPR000504; RRM_dom. 
Pfam
 PF00076; RRM_1 
SMART
 SM00360; RRM 
PROSITE
 PS50102; RRM 
PRINTS