UniProt Accession

 B4DU28_HUMAN; B4DU28 

Genbank Protein ID

 AC018904; AC091046; AK300472 

Genbank Nucleotide ID

 BAG62190.1 

Protein Name

 Disintegrin and metalloproteinase domain-containing protein 10 

Protein Synonyms/Alias

 cDNA FLJ57594, highly similar to ADAM 10 (EC 3.4.24.81) (Adisintegrin and metalloproteinase domain 10) 

Gene Name

 ADAM10 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
109	ESKNLGQKENGNYIM	ubiquitination	[1]
300	CHVCCMKKMDPSTCA	ubiquitination	[1]
420	KPLPGTLKRRRPPQP	ubiquitination	[1, 2]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Disulfide bond; Integrin; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 447 AA 

Protein Sequence

Gene Ontology

 GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
 GO:0006509; P:membrane protein ectodomain proteolysis; IEA:InterPro.
 GO:0007219; P:Notch signaling pathway; IEA:InterPro. 

Interpro

 IPR027053; ADAM_10.
 IPR001762; Blood-coag_inhib_Disintegrin.
 IPR024079; MetalloPept_cat_dom.
 IPR001590; Peptidase_M12B. 

Pfam

 PF00200; Disintegrin 

SMART

 SM00050; DISIN 

PROSITE

 PS50215; ADAM_MEPRO
 PS50214; DISINTEGRIN_2 

PRINTS