CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-035446
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Peptidyl-glycine alpha-amidating monooxygenase 
Protein Synonyms/Alias
  
Gene Name
 Pam 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
709WKFTLTEKMEHRSVKacetylation[1]
800FGADHDRKLESSSGRubiquitination[2]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 872 AA 
Protein Sequence
MAGRARSGLL LLLLGLLALQ SSCLAFRSPL SVFKRFKETT RSFSNECLGT IGPVTPLDAS 60
DFALDIRMPG VTPKESDTYF CMSMRLPVDE EAFVIDFKPR ASMDTVHHML LFGCNMPSST 120
GSYWFCDEGT CTDKANILYA WARNAPPTRL PKGVGFRVGG ETGSKYFVLQ VHYGDISAFR 180
DNHKDCSGVS VHLTRVPQPL IAGMYLMMSV DTVIPPGEKV VNADISCQYK MYPMHVFAYR 240
VHTHHLGKVV SGYRVRNGQW TLIGRQNPQL PQAFYPVEHP VDVTFGDILA ARCVFTGEGR 300
TEATHIGGTS SDEMCNLYIM YYMEAKYALS FMTCTKNVAP DMFRTIPAEA NIPIPVKPDM 360
VMMHGHHKEA ENKEKSALMQ QPKQGEEEVL EQDFHVEEEL DWPGVYLLPG QVSGVALDSK 420
NNLVIFHRGD HVWDGNSFDS KFVYQQRGLG PIEEDTILVI DPNNAEILQS SGKNLFYLPH 480
GLSIDTDGNY WVTDVALHQV FKLDPHSKEG PLLILGRSMQ PGSDQNHFCQ PTDVAVEPST 540
GAVFVSDGYC NSRIVQFSPS GKFVTQWGEE SSGSSPRPGQ FSVPHSLALV PHLDQLCVAD 600
RENGRIQCFK TDTKEFVREI KHASFGRNVF AISYIPGFLF AVNGKPYFGD QEPVQGFVMN 660
FSSGEIIDVF KPVRKHFDMP HDIVASEDGT VYIGDAHTNT VWKFTLTEKM EHRSVKKAGI 720
EVQEIKEAEA VVEPKVENKP TSSELQKMQE KQKLSTEPGS GVSVVLITTL LVIPVLVLLA 780
IVMFIRWKKS RAFGADHDRK LESSSGRVLG RFRGKGSGGL NLGNFFASRK GYSRKGFDRV 840
STEGSDQEKD EDDGTESEEE YSAPLPKPAP SS 872 
Gene Ontology
 GO:0016020; C:membrane; IEA:InterPro.
 GO:0005507; F:copper ion binding; IEA:InterPro.
 GO:0004504; F:peptidylglycine monooxygenase activity; IEA:InterPro.
 GO:0006518; P:peptide metabolic process; IEA:InterPro. 
Interpro
 IPR011042; 6-blade_b-propeller_TolB-like.
 IPR014784; Cu2_ascorb_mOase-like_C.
 IPR020611; Cu2_ascorb_mOase_CS-1.
 IPR014783; Cu2_ascorb_mOase_CS-2.
 IPR000323; Cu2_ascorb_mOase_N.
 IPR001258; NHL_repeat.
 IPR013017; NHL_repeat_subgr.
 IPR000720; Pep_amidat_mOase.
 IPR008977; PHM/PNGase_F_dom. 
Pfam
 PF01082; Cu2_monooxygen
 PF01436; NHL 
SMART
  
PROSITE
 PS00084; CU2_MONOOXYGENASE_1
 PS00085; CU2_MONOOXYGENASE_2
 PS51125; NHL 
PRINTS
 PR00790; PAMONOXGNASE.