UniProt Accession

 ACTC_RAT; P68035; A0JPJ4; P04270 

Genbank Protein ID

 X80130; BC127451 

Genbank Nucleotide ID

 CAA56429.1; AAI27452.1 

Protein Name

 Actin, alpha cardiac muscle 1 

Protein Synonyms/Alias

 Alpha-cardiac actin 

Gene Name

 Actc1 

Gene Synonyms/Alias

 Actc 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
86	TNWDDMEKIWHHTFY	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. 

Sequence Annotation

 MOD_RES 3 3 N-acetylaspartate (By similarity).
 MOD_RES 46 46 Methionine sulfoxide (By similarity).
 MOD_RES 55 55 Phosphotyrosine (By similarity).
 MOD_RES 75 75 Tele-methylhistidine (By similarity).
 MOD_RES 93 93 Phosphotyrosine (By similarity).
 MOD_RES 242 242 Phosphotyrosine (By similarity).  

Keyword

 Acetylation; ATP-binding; Complete proteome; Cytoplasm; Cytoskeleton; Methylation; Muscle protein; Nucleotide-binding; Oxidation; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 377 AA 

Protein Sequence

Gene Ontology

 GO:0042643; C:actomyosin, actin part; IEA:Compara.
 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0031674; C:I band; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:Compara.
 GO:0033275; P:actin-myosin filament sliding; IEA:Compara.
 GO:0006915; P:apoptotic process; IEA:Compara.
 GO:0060048; P:cardiac muscle contraction; IDA:RGD.
 GO:0055008; P:cardiac muscle tissue morphogenesis; IEA:Compara.
 GO:0055003; P:cardiac myofibril assembly; IEA:Compara.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0045471; P:response to ethanol; IEP:RGD.
 GO:0030240; P:skeletal muscle thin filament assembly; IEA:Compara. 

Interpro

 IPR004000; Actin-related.
 IPR020902; Actin/actin-like_CS.
 IPR004001; Actin_CS. 

Pfam

 PF00022; Actin 

SMART

 SM00268; ACTIN 

PROSITE

 PS00406; ACTINS_1
 PS00432; ACTINS_2
 PS01132; ACTINS_ACT_LIKE 

PRINTS

 PR00190; ACTIN.