CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019971
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SEC14-like protein 2 
Protein Synonyms/Alias
 Alpha-tocopherol-associated protein; TAP; Squalene transfer protein; Supernatant protein factor; SPF 
Gene Name
 Sec14l2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
11RVGDLSPKQEEALAKubiquitination[1]
275YYVRDQVKQQYEHSVubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 Carrier protein. Binds to some hydrophobic molecules and promotes their transfer between the different cellular sites. Binds with high affinity to alpha-tocopherol. Also binds with a weaker affinity to other tocopherols and to tocotrienols. May have a transcriptional activatory activity via its association with alpha-tocopherol (By similarity). Probably recognizes and binds some squalene structure, suggesting that it may regulate cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell. 
Sequence Annotation
 DOMAIN 76 249 CRAL-TRIO.
 DOMAIN 275 383 GOLD.  
Keyword
 Activator; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Lipid-binding; Nucleus; Reference proteome; Transcription; Transcription regulation; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 403 AA 
Protein Sequence
MSGRVGDLSP KQEEALAKFR ENVQDVLPAL PNPDDYFLLR WLRARSFDLQ KSEAMLRKHV 60
EFRKQKDIDK IISWQPPEVI QQYLSGGRCG YDLDGCPVWY DIIGPLDAKG LLFSASKQDL 120
LRTKMRDCEL LLQECTQQTA KLGKKIETIT MIYDCEGLGL KHLWKPAVEA YGEFLTMFEE 180
NYPETLKRLF VVKAPKLFPV AYNLIKPFLS EDTRKKIMVL GANWKEVLLK HISPDQLPVE 240
YGGTMTDPDG NPKCKSKINY GGDIPKQYYV RDQVKQQYEH SVQISRGSSH QVEYEILFPG 300
CVLRWQFMSE GSDVGFGIFL KTKMGERQRA GEMTEVLPNQ RYNSHMVPED GTLTCSEPGI 360
YVLRFDNTYS FIHAKKVSFT VEVLLPDKAA EEKLNQQGAV TPK 403 
Gene Ontology
 GO:0005829; C:cytosol; IDA:RGD.
 GO:0016021; C:integral to membrane; IEA:InterPro.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0008047; F:enzyme activator activity; IDA:RGD.
 GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
 GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IDA:RGD.
 GO:0005215; F:transporter activity; IEA:InterPro.
 GO:0045542; P:positive regulation of cholesterol biosynthetic process; IDA:RGD.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR001071; CRAL-bd_toc_tran.
 IPR001251; CRAL-TRIO_dom.
 IPR011074; CRAL/TRIO_N_dom.
 IPR009038; GOLD. 
Pfam
 PF00650; CRAL_TRIO
 PF03765; CRAL_TRIO_N 
SMART
 SM01100; CRAL_TRIO_N
 SM00516; SEC14 
PROSITE
 PS50191; CRAL_TRIO
 PS50866; GOLD 
PRINTS
 PR00180; CRETINALDHBP.